Biomimetic creation of cortical-like bone with hierarchical structure

Project: Research project

Project Details

Description

1033742

Wang

This is a proposal for a bottoms-up engineering of bone tissue focusing on engineering cortical bone, the major load bearing component of bone. This approach contrasts with the current state-of-the-art that focuses on creating highly porous cancellous bone.

The work proposes a creative approach that combines ideas from modular assembly of small tissue building blocks to form large constructs, nano-structured scaffolds, and tissue culture to cellular engraftment upon these structures. The educational broader impacts of the proposed work are graduate student education and research, the development of underrepresented groups, the engagement of a local community college, the inclusion of high school student research activities, and course development.

StatusFinished
Effective start/end date1/10/1030/09/14

Funding

  • National Science Foundation

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