5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment

M. K.Khaing Oo, X. Yang, H. Wang, H. Du

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

In photodynamic therapy (PDT) for cancer treatment, effective delivery of photosensitizer to the target tumor and minimal damage to the healthy cell is of paramount importance. In this study novel biocompatible positively charged (ξ = +33 mV) gold nanoparticles (30 nm average diameter) are conjugated with a photosensitizing precursor, 5-aminolevulinic acid (ALA) at physiological pH (pH 7.2 to 7.6). As verified by fluorescence spectroscopy of protoporphyrin IX (PpIX), they are preferentially accumulated on the tumor cells. They are found to promote the formation of reactive oxygen species (ROS) and significantly increase the killing efficiency of WT cells. Furthermore, the gold nanoparticles exhibit surface-enhanced Raman scattering (SERS) activity, making them a powerful imaging vehicle for the monitoring of cellular molecular events during cancer treatment using PDT.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages12-15
Number of pages4
StatePublished - 2008
Event2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States
Duration: 1 Jun 20085 Jun 2008

Publication series

NameTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Volume2

Conference

Conference2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
Country/TerritoryUnited States
CityQuebec City, QC
Period1/06/085/06/08

Keywords

  • Nanoparticles
  • Photodynamic therapy
  • Photosensitizer
  • Surface-enhanced Raman scattering

Fingerprint

Dive into the research topics of '5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment'. Together they form a unique fingerprint.

Cite this