TY - GEN
T1 - 5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment
AU - Oo, M. K.Khaing
AU - Yang, X.
AU - Wang, H.
AU - Du, H.
PY - 2008
Y1 - 2008
N2 - In photodynamic therapy (PDT) for cancer treatment, effective delivery of photosensitizer to the target tumor and minimal damage to the healthy cell is of paramount importance. In this study novel biocompatible positively charged (ξ = +33 mV) gold nanoparticles (30 nm average diameter) are conjugated with a photosensitizing precursor, 5-aminolevulinic acid (ALA) at physiological pH (pH 7.2 to 7.6). As verified by fluorescence spectroscopy of protoporphyrin IX (PpIX), they are preferentially accumulated on the tumor cells. They are found to promote the formation of reactive oxygen species (ROS) and significantly increase the killing efficiency of WT cells. Furthermore, the gold nanoparticles exhibit surface-enhanced Raman scattering (SERS) activity, making them a powerful imaging vehicle for the monitoring of cellular molecular events during cancer treatment using PDT.
AB - In photodynamic therapy (PDT) for cancer treatment, effective delivery of photosensitizer to the target tumor and minimal damage to the healthy cell is of paramount importance. In this study novel biocompatible positively charged (ξ = +33 mV) gold nanoparticles (30 nm average diameter) are conjugated with a photosensitizing precursor, 5-aminolevulinic acid (ALA) at physiological pH (pH 7.2 to 7.6). As verified by fluorescence spectroscopy of protoporphyrin IX (PpIX), they are preferentially accumulated on the tumor cells. They are found to promote the formation of reactive oxygen species (ROS) and significantly increase the killing efficiency of WT cells. Furthermore, the gold nanoparticles exhibit surface-enhanced Raman scattering (SERS) activity, making them a powerful imaging vehicle for the monitoring of cellular molecular events during cancer treatment using PDT.
KW - Nanoparticles
KW - Photodynamic therapy
KW - Photosensitizer
KW - Surface-enhanced Raman scattering
UR - http://www.scopus.com/inward/record.url?scp=52749096681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52749096681&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:52749096681
SN - 9781420085075
SN - 9781420085044
T3 - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
SP - 12
EP - 15
BT - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
T2 - 2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
Y2 - 1 June 2008 through 5 June 2008
ER -