5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment

M. K.Khaing Oo; X. Yang; H. Wang; H. Du

5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment

M. K.Khaing Oo
, X. Yang
, H. Wang
, H. Du

Stevens Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

In photodynamic therapy (PDT) for cancer treatment, effective delivery of photosensitizer to the target tumor and minimal damage to the healthy cell is of paramount importance. In this study novel biocompatible positively charged (ξ = +33 mV) gold nanoparticles (30 nm average diameter) are conjugated with a photosensitizing precursor, 5-aminolevulinic acid (ALA) at physiological pH (pH 7.2 to 7.6). As verified by fluorescence spectroscopy of protoporphyrin IX (PpIX), they are preferentially accumulated on the tumor cells. They are found to promote the formation of reactive oxygen species (ROS) and significantly increase the killing efficiency of WT cells. Furthermore, the gold nanoparticles exhibit surface-enhanced Raman scattering (SERS) activity, making them a powerful imaging vehicle for the monitoring of cellular molecular events during cancer treatment using PDT.

Original language	English
Title of host publication	Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages	12-15
Number of pages	4
State	Published - 2008
Event	2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States Duration: 1 Jun 2008 → 5 Jun 2008

Publication series

Name	Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Volume	2

Conference

Conference	2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
Country/Territory	United States
City	Quebec City, QC
Period	1/06/08 → 5/06/08

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Nanoparticles
Photodynamic therapy
Photosensitizer
Surface-enhanced Raman scattering

Cite this

Oo, M. K. K., Yang, X., Wang, H., & Du, H. (2008). 5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008 (pp. 12-15). (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008; Vol. 2).

Oo, M. K.Khaing ; Yang, X. ; Wang, H. et al. / 5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment. Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. 2008. pp. 12-15 (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008).

@inproceedings{de1f1631a9404cd499bdcd938137cd93,

title = "5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment",

abstract = "In photodynamic therapy (PDT) for cancer treatment, effective delivery of photosensitizer to the target tumor and minimal damage to the healthy cell is of paramount importance. In this study novel biocompatible positively charged (ξ = +33 mV) gold nanoparticles (30 nm average diameter) are conjugated with a photosensitizing precursor, 5-aminolevulinic acid (ALA) at physiological pH (pH 7.2 to 7.6). As verified by fluorescence spectroscopy of protoporphyrin IX (PpIX), they are preferentially accumulated on the tumor cells. They are found to promote the formation of reactive oxygen species (ROS) and significantly increase the killing efficiency of WT cells. Furthermore, the gold nanoparticles exhibit surface-enhanced Raman scattering (SERS) activity, making them a powerful imaging vehicle for the monitoring of cellular molecular events during cancer treatment using PDT.",

keywords = "Nanoparticles, Photodynamic therapy, Photosensitizer, Surface-enhanced Raman scattering",

author = "Oo, \{M. K.Khaing\} and X. Yang and H. Wang and H. Du",

year = "2008",

language = "English",

isbn = "9781420085075",

series = "Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008",

pages = "12--15",

booktitle = "Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008",

note = "2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 ; Conference date: 01-06-2008 Through 05-06-2008",

}

Oo, MKK, Yang, X, Wang, H & Du, H 2008, 5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment. in Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, vol. 2, pp. 12-15, 2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008, Quebec City, QC, United States, 1/06/08.

5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment. / Oo, M. K.Khaing; Yang, X.; Wang, H. et al.
Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. 2008. p. 12-15 (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008; Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - 5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment

AU - Oo, M. K.Khaing

AU - Yang, X.

AU - Wang, H.

AU - Du, H.

PY - 2008

Y1 - 2008

N2 - In photodynamic therapy (PDT) for cancer treatment, effective delivery of photosensitizer to the target tumor and minimal damage to the healthy cell is of paramount importance. In this study novel biocompatible positively charged (ξ = +33 mV) gold nanoparticles (30 nm average diameter) are conjugated with a photosensitizing precursor, 5-aminolevulinic acid (ALA) at physiological pH (pH 7.2 to 7.6). As verified by fluorescence spectroscopy of protoporphyrin IX (PpIX), they are preferentially accumulated on the tumor cells. They are found to promote the formation of reactive oxygen species (ROS) and significantly increase the killing efficiency of WT cells. Furthermore, the gold nanoparticles exhibit surface-enhanced Raman scattering (SERS) activity, making them a powerful imaging vehicle for the monitoring of cellular molecular events during cancer treatment using PDT.

AB - In photodynamic therapy (PDT) for cancer treatment, effective delivery of photosensitizer to the target tumor and minimal damage to the healthy cell is of paramount importance. In this study novel biocompatible positively charged (ξ = +33 mV) gold nanoparticles (30 nm average diameter) are conjugated with a photosensitizing precursor, 5-aminolevulinic acid (ALA) at physiological pH (pH 7.2 to 7.6). As verified by fluorescence spectroscopy of protoporphyrin IX (PpIX), they are preferentially accumulated on the tumor cells. They are found to promote the formation of reactive oxygen species (ROS) and significantly increase the killing efficiency of WT cells. Furthermore, the gold nanoparticles exhibit surface-enhanced Raman scattering (SERS) activity, making them a powerful imaging vehicle for the monitoring of cellular molecular events during cancer treatment using PDT.

KW - Nanoparticles

KW - Photodynamic therapy

KW - Photosensitizer

KW - Surface-enhanced Raman scattering

UR - https://www.scopus.com/pages/publications/52749096681

UR - https://www.scopus.com/pages/publications/52749096681#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:52749096681

SN - 9781420085075

SN - 9781420085044

T3 - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008

SP - 12

EP - 15

BT - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008

T2 - 2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008

Y2 - 1 June 2008 through 5 June 2008

ER -

5-Aminolevulinic acid conjugated gold nanoparticles for cancer treatment

Abstract

Publication series

Conference

UN SDGs

Keywords

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