TY - CHAP
T1 - A Biomimetic Approach toward the Fabrication of Epithelial-like Tissue
AU - Wang, Hongjun
AU - Xu, Meng
N1 - Publisher Copyright:
© 2014 John Wiley & Sons, Inc..
PY - 2014/4/14
Y1 - 2014/4/14
N2 - The skin is the largest organ and covers the entire exterior surface of the body. Nanofibrous matrices prepared from electrospinning can maximally recapture the dimension and morphology of native extracellular matrix (ECM) and support the adhesion and growth of various cells, showing great potential in the field of skin tissue engineering. This chapter highlights how various nanofibrous matrices are prepared. It explains the fabrication of nanofibrous scaffold for skin tissue regeneration. In addition, various parameters of biomimetic nanofibrous scaffolds that regulate tissue formation are discussed and their utilization for creating skin grafts is highlighted. Also, the fabrication method may provide an ideal system for drug and/or growth factor incorporation into polymers used as skin tissue engineering matrices. To better support the formation of skin-like tissue, it is crucial for the skin cells to experience a microenvironment that is as similar to their native one as much as possible.
AB - The skin is the largest organ and covers the entire exterior surface of the body. Nanofibrous matrices prepared from electrospinning can maximally recapture the dimension and morphology of native extracellular matrix (ECM) and support the adhesion and growth of various cells, showing great potential in the field of skin tissue engineering. This chapter highlights how various nanofibrous matrices are prepared. It explains the fabrication of nanofibrous scaffold for skin tissue regeneration. In addition, various parameters of biomimetic nanofibrous scaffolds that regulate tissue formation are discussed and their utilization for creating skin grafts is highlighted. Also, the fabrication method may provide an ideal system for drug and/or growth factor incorporation into polymers used as skin tissue engineering matrices. To better support the formation of skin-like tissue, it is crucial for the skin cells to experience a microenvironment that is as similar to their native one as much as possible.
KW - Extracellular matrix (ECM)
KW - Nanofibrous matrices
KW - Scaffold design
KW - Skin tissue regeneration
KW - Skin-like tissue
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U2 - 10.1002/9781118843499.ch11
DO - 10.1002/9781118843499.ch11
M3 - Chapter
AN - SCOPUS:84927023070
SN - 9781118369364
VL - 9781118369364
SP - 175
EP - 194
BT - Bio-inspired Materials for Biomedical Engineering
ER -