A Biomimetic Approach toward the Fabrication of Epithelial-like Tissue

The skin is the largest organ and covers the entire exterior surface of the body. Nanofibrous matrices prepared from electrospinning can maximally recapture the dimension and morphology of native extracellular matrix (ECM) and support the adhesion and growth of various cells, showing great potential in the field of skin tissue engineering. This chapter highlights how various nanofibrous matrices are prepared. It explains the fabrication of nanofibrous scaffold for skin tissue regeneration. In addition, various parameters of biomimetic nanofibrous scaffolds that regulate tissue formation are discussed and their utilization for creating skin grafts is highlighted. Also, the fabrication method may provide an ideal system for drug and/or growth factor incorporation into polymers used as skin tissue engineering matrices. To better support the formation of skin-like tissue, it is crucial for the skin cells to experience a microenvironment that is as similar to their native one as much as possible.