TY - JOUR
T1 - A comparison of epithelial-to-mesenchymal transition and re-epithelialization
AU - Leopold, Philip L.
AU - Vincent, Jan
AU - Wang, Hongjun
PY - 2012/10
Y1 - 2012/10
N2 - Wound healing and cancer metastasis share a common starting point, namely, a change in the phenotype of some cells from stationary to motile. The term, epithelial-to-mesenchymal transition (EMT) describes the changes in molecular biology and cellular physiology that allow a cell to transition from a sedentary cell to a motile cell, a process that is relevant not only for cancer and regeneration, but also for normal development of multicellular organisms. The present review compares the similarities and differences in cellular response at the molecular level as tumor cells enter EMT or as keratinocytes begin the process of re-epithelialization of a wound. Looking toward clinical interventions that might modulate these processes, the mechanisms and outcomes of current and potential therapies are reviewed for both anti-cancer and pro-wound healing treatments related to the pathways that are central to EMT. Taken together, the comparison of re-epithelialization and tumor EMT serves as a starting point for the development of therapies that can selectively modulate different forms of EMT.
AB - Wound healing and cancer metastasis share a common starting point, namely, a change in the phenotype of some cells from stationary to motile. The term, epithelial-to-mesenchymal transition (EMT) describes the changes in molecular biology and cellular physiology that allow a cell to transition from a sedentary cell to a motile cell, a process that is relevant not only for cancer and regeneration, but also for normal development of multicellular organisms. The present review compares the similarities and differences in cellular response at the molecular level as tumor cells enter EMT or as keratinocytes begin the process of re-epithelialization of a wound. Looking toward clinical interventions that might modulate these processes, the mechanisms and outcomes of current and potential therapies are reviewed for both anti-cancer and pro-wound healing treatments related to the pathways that are central to EMT. Taken together, the comparison of re-epithelialization and tumor EMT serves as a starting point for the development of therapies that can selectively modulate different forms of EMT.
KW - Dermal wound healing
KW - Epithelial-to-mesenchymal transition
KW - Growth factors
KW - Keratinocyte
KW - Metastasis
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U2 - 10.1016/j.semcancer.2012.07.003
DO - 10.1016/j.semcancer.2012.07.003
M3 - Review article
C2 - 22863788
AN - SCOPUS:84866341656
SN - 1044-579X
VL - 22
SP - 471
EP - 483
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
IS - 5-6
ER -