Abstract
Compound 4 prepared from Isatin in two steps underwent an unusual radical-induced rearrangement reaction to yield 9 as the major product and 10 as the minor component. Compound 9 shows structural similarities to the antimitotic agent rhazinilam and the gamma secretase inhibitor LY411575. The scope of the reaction has been studied by changing the substitutions on the aromatic rings and the mechanism for the formation of 9 and 10 from 4 is suggested.
Original language | English |
---|---|
Pages (from-to) | 1879-1881 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 50 |
Issue number | 17 |
DOIs | |
State | Published - 29 Apr 2009 |
Keywords
- Ortho-ortho disubstituted biphenyls
- Radical reaction