A facile diversity-oriented synthesis of imidazo[1,2-a]pyrazinones via gold-catalyzed regioselective heteroannulation of propynylaminopyrazinones

Dipak D. Vachhani, Sachin G. Modha, Abhishek Sharma, Erik V. Van Der Eycken

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A gold-catalyzed regioselective heteroannulation strategy has been developed for the concise and efficient synthesis of imidazo[1,2-a]pyrazinones. The protocol allows the introduction of diversity via the application of substituted propargyl amines or via Suzuki-coupling of the generated imidazo[1,2-a]pyrazinones with various (het)aryl boronic acids.

Original languageEnglish
Pages (from-to)359-365
Number of pages7
JournalTetrahedron
Volume69
Issue number1
DOIs
StatePublished - 7 Jan 2013

Keywords

  • Alkyne
  • Gold
  • Heteroannulation
  • Imidazopyrazinone
  • Suzuki

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