A graphene nanosensor for detection of small molecules

Cheng Wang, Jinho Kim, Jing Zhu, Renjun Pei, Guohua Liu, James Hone, Milan Stojanovic, Qiao Lin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

This paper presents an aptamer-based graphene nanosensor capable of detecting small molecules. To address difficulties in direct detection of small moelcules associated with their low electric charges, we use a competitive sensing approach as demonstrated with dehydroepiandrosterone sulfate (DHEA-S) as a target analyte, which is a small molecular steroid hormone with important applications in clinical diagnostics. A DHEA-S aptamer is captured by a complementary short DNA probe immobilized on the graphene and released upon exposure to DHEA-S in solution due to the binding between DHEA-S and the aptamer. The aptamer release is detected by measuring the change in the conductivity of graphene. Experimental results show that the time rate of aptamer release from the graphene is inversely proportional to DHEA-S concentration in solution. Thus, the nanosensor can potentially enable label-free, specific and quantitative measurement of DHEA-S and other small molecules.

Original languageEnglish
Title of host publicationMEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems
Pages1075-1078
Number of pages4
DOIs
StatePublished - 2014
Event27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014 - San Francisco, CA, United States
Duration: 26 Jan 201430 Jan 2014

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Conference

Conference27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014
Country/TerritoryUnited States
CitySan Francisco, CA
Period26/01/1430/01/14

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