TY - JOUR
T1 - A less toxic heparin antagonist - Low molecular weight protamine
AU - Liang, J. F.
AU - Zhen, L.
AU - Chang, L. C.
AU - Yang, V. C.
PY - 2003/1
Y1 - 2003/1
N2 - A new thirteen amino acid peptide, named low molecular weight protamine (LMWP), was obtained through the enzymatic digestion of native protamine. Both in vitro and in vivo results showed that LMWP fully maintained the heparin neutralization function of protamine but had much lower immunogenicity and antigenicity. Unlike protamine, neither LMWP nor LMWP/heparin complexes caused significant blood platelet aggregation in rats. These results suggest that LMWP can be used as a substitute for protamine for developing a new generation of nontoxic heparin antagonists.
AB - A new thirteen amino acid peptide, named low molecular weight protamine (LMWP), was obtained through the enzymatic digestion of native protamine. Both in vitro and in vivo results showed that LMWP fully maintained the heparin neutralization function of protamine but had much lower immunogenicity and antigenicity. Unlike protamine, neither LMWP nor LMWP/heparin complexes caused significant blood platelet aggregation in rats. These results suggest that LMWP can be used as a substitute for protamine for developing a new generation of nontoxic heparin antagonists.
KW - Heparin neutralization
KW - Immunogenicity
KW - Low molecular weight protamine
KW - Platelet aggregation
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U2 - 10.1023/A:1022109905487
DO - 10.1023/A:1022109905487
M3 - Article
C2 - 12693985
AN - SCOPUS:0037237027
SN - 0006-2979
VL - 68
SP - 116
EP - 120
JO - Biochemistry (Moscow)
JF - Biochemistry (Moscow)
IS - 1
ER -