A less toxic heparin antagonist - Low molecular weight protamine

J. F. Liang, L. Zhen, L. C. Chang, V. C. Yang

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

A new thirteen amino acid peptide, named low molecular weight protamine (LMWP), was obtained through the enzymatic digestion of native protamine. Both in vitro and in vivo results showed that LMWP fully maintained the heparin neutralization function of protamine but had much lower immunogenicity and antigenicity. Unlike protamine, neither LMWP nor LMWP/heparin complexes caused significant blood platelet aggregation in rats. These results suggest that LMWP can be used as a substitute for protamine for developing a new generation of nontoxic heparin antagonists.

Original languageEnglish
Pages (from-to)116-120
Number of pages5
JournalBiochemistry (Moscow)
Volume68
Issue number1
DOIs
StatePublished - Jan 2003

Keywords

  • Heparin neutralization
  • Immunogenicity
  • Low molecular weight protamine
  • Platelet aggregation

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