TY - JOUR
T1 - A linker approach to phospholipopeptides
AU - Li, Bonan
AU - Liang, Jun F.
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Peptides and phospholipids are important macromolecules in both the chemistry and biology fields, but phospholipopeptides are barely found in nature and have not been studied. Here, we report a novel and efficient approach to the synthesis of phospholipidpeptides. By utilizing cross-linkers, phospholipopeptides from peptides with varied sequences and lengths were produced from phosphatidylethanolamine at high (>90%) yield, mild conditions and good applied scopes for multiple substrates. Synthetic phospholipopeptides containing bioactive peptide sequences may serve as therapeutics for a wide range of biomedical applications. Practical applications: Phospholipopeptides are prone to hydrolysis by the endogenous phospholipase activity in cells. Synthetic phospholipopeptides containing a bioactive peptide sequences may serve as therapeutics for a wide range of biomedical applications.
AB - Peptides and phospholipids are important macromolecules in both the chemistry and biology fields, but phospholipopeptides are barely found in nature and have not been studied. Here, we report a novel and efficient approach to the synthesis of phospholipidpeptides. By utilizing cross-linkers, phospholipopeptides from peptides with varied sequences and lengths were produced from phosphatidylethanolamine at high (>90%) yield, mild conditions and good applied scopes for multiple substrates. Synthetic phospholipopeptides containing bioactive peptide sequences may serve as therapeutics for a wide range of biomedical applications. Practical applications: Phospholipopeptides are prone to hydrolysis by the endogenous phospholipase activity in cells. Synthetic phospholipopeptides containing a bioactive peptide sequences may serve as therapeutics for a wide range of biomedical applications.
KW - Conjugation
KW - Cross-linker
KW - Lipopeptide
KW - Liposomes
KW - Peptides
UR - http://www.scopus.com/inward/record.url?scp=84956758653&partnerID=8YFLogxK
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U2 - 10.1002/ejlt.201400593
DO - 10.1002/ejlt.201400593
M3 - Article
AN - SCOPUS:84956758653
SN - 1438-7697
VL - 118
SP - 273
EP - 278
JO - European Journal of Lipid Science and Technology
JF - European Journal of Lipid Science and Technology
IS - 2
ER -