A Microfluidic Ion Pump for In Vivo Drug Delivery

Ilke Uguz; Christopher M. Proctor; Vincenzo F. Curto; Anna Maria Pappa; Mary J. Donahue; Magali Ferro; Róisín M. Owens; Dion Khodagholy; Sahika Inal; George G. Malliaras

doi:10.1002/adma.201701217

A Microfluidic Ion Pump for In Vivo Drug Delivery

Ilke Uguz
, Christopher M. Proctor
, Vincenzo F. Curto
, Anna Maria Pappa
, Mary J. Donahue
, Magali Ferro
, Róisín M. Owens
, Dion Khodagholy
, Sahika Inal
, George G. Malliaras

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.

Original language	English
Article number	1701217
Journal	Advanced Materials
Volume	29
Issue number	27
DOIs	https://doi.org/10.1002/adma.201701217
State	Published - 19 Jul 2017

Keywords

organic bioelectronics
organic electronic ion pumps
PEDOT:PSS

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10.1002/adma.201701217

Cite this

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abstract = "Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.",

keywords = "organic bioelectronics, organic electronic ion pumps, PEDOT:PSS",

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T1 - A Microfluidic Ion Pump for In Vivo Drug Delivery

AU - Uguz, Ilke

AU - Proctor, Christopher M.

AU - Curto, Vincenzo F.

AU - Pappa, Anna Maria

AU - Donahue, Mary J.

AU - Ferro, Magali

AU - Owens, Róisín M.

AU - Khodagholy, Dion

AU - Inal, Sahika

AU - Malliaras, George G.

PY - 2017/7/19

Y1 - 2017/7/19

N2 - Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.

AB - Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.

KW - organic bioelectronics

KW - organic electronic ion pumps

KW - PEDOT:PSS

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JF - Advanced Materials

IS - 27

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ER -

A Microfluidic Ion Pump for In Vivo Drug Delivery

Abstract

Keywords

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