A Porous Bimetallic Au@Pt Core-Shell Oxygen Generator to Enhance Hypoxia-Dampened Tumor Chemotherapy Synergized with NIR-II Photothermal Therapy

Jingyu Sun, Jinping Wang, Wei Hu, Yuhao Wang, Qiang Zhang, Xiaotong Hu, Tsengming Chou, Beilu Zhang, Cosmo Gallaro, Meghan Halloran, Lyu Liang, Lei Ren, Hongjun Wang

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The characteristic hypoxia of solid tumors and inadequate oxygen supply become a key causation of the resistance to chemotherapy in cancer treatment. Herein, a bimetallic oxygen nanogenerator, i.e., porous Au@Pt core-shell nanostructures, is particularly developed to reduce the multidrug resistance by oxygenating the tumor along with synergistic chemo-photothermal therapy for efficient tumor eradication. The porous platinum (Pt) shell was able to catalyze oxygen generation from endogenous hydrogen peroxide in the tumor, reducing the exocytosis of doxorubicin (DOX) via suppressed expression of hypoxia-inducible factor-1α, multidrug resistance gene 1, and P-glycoprotein. The strong absorbance of Au@Pt nanostructures in NIR window II enabled NIR-II photothermal therapy. Further incorporation of DOX into the mesopores of Au@Pt nanostructures with the assistance of phase change materials (PCM) led to the formulation of Au@Pt-DOX-PCM-PEG nanotherapeutics for NIR-II-activated chemotherapy. This work presents an efficient H2O2-driven oxygenerator for enhanced hypoxia-dampened chemotherapy and NIR-II photothermal therapy.

Original languageEnglish
Pages (from-to)10711-10728
Number of pages18
JournalACS Nano
Volume16
Issue number7
DOIs
StatePublished - 26 Jul 2022

Keywords

  • chemotherapy
  • endogenous oxygenation
  • hypoxia alleviation
  • near-infrared second window (NIR-II) photothermal therapy
  • porous platinum/gold core-shell nanoenzyme

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