TY - JOUR
T1 - A Porous Bimetallic Au@Pt Core-Shell Oxygen Generator to Enhance Hypoxia-Dampened Tumor Chemotherapy Synergized with NIR-II Photothermal Therapy
AU - Sun, Jingyu
AU - Wang, Jinping
AU - Hu, Wei
AU - Wang, Yuhao
AU - Zhang, Qiang
AU - Hu, Xiaotong
AU - Chou, Tsengming
AU - Zhang, Beilu
AU - Gallaro, Cosmo
AU - Halloran, Meghan
AU - Liang, Lyu
AU - Ren, Lei
AU - Wang, Hongjun
N1 - Publisher Copyright:
© 2022 American Chemical Society.
PY - 2022/7/26
Y1 - 2022/7/26
N2 - The characteristic hypoxia of solid tumors and inadequate oxygen supply become a key causation of the resistance to chemotherapy in cancer treatment. Herein, a bimetallic oxygen nanogenerator, i.e., porous Au@Pt core-shell nanostructures, is particularly developed to reduce the multidrug resistance by oxygenating the tumor along with synergistic chemo-photothermal therapy for efficient tumor eradication. The porous platinum (Pt) shell was able to catalyze oxygen generation from endogenous hydrogen peroxide in the tumor, reducing the exocytosis of doxorubicin (DOX) via suppressed expression of hypoxia-inducible factor-1α, multidrug resistance gene 1, and P-glycoprotein. The strong absorbance of Au@Pt nanostructures in NIR window II enabled NIR-II photothermal therapy. Further incorporation of DOX into the mesopores of Au@Pt nanostructures with the assistance of phase change materials (PCM) led to the formulation of Au@Pt-DOX-PCM-PEG nanotherapeutics for NIR-II-activated chemotherapy. This work presents an efficient H2O2-driven oxygenerator for enhanced hypoxia-dampened chemotherapy and NIR-II photothermal therapy.
AB - The characteristic hypoxia of solid tumors and inadequate oxygen supply become a key causation of the resistance to chemotherapy in cancer treatment. Herein, a bimetallic oxygen nanogenerator, i.e., porous Au@Pt core-shell nanostructures, is particularly developed to reduce the multidrug resistance by oxygenating the tumor along with synergistic chemo-photothermal therapy for efficient tumor eradication. The porous platinum (Pt) shell was able to catalyze oxygen generation from endogenous hydrogen peroxide in the tumor, reducing the exocytosis of doxorubicin (DOX) via suppressed expression of hypoxia-inducible factor-1α, multidrug resistance gene 1, and P-glycoprotein. The strong absorbance of Au@Pt nanostructures in NIR window II enabled NIR-II photothermal therapy. Further incorporation of DOX into the mesopores of Au@Pt nanostructures with the assistance of phase change materials (PCM) led to the formulation of Au@Pt-DOX-PCM-PEG nanotherapeutics for NIR-II-activated chemotherapy. This work presents an efficient H2O2-driven oxygenerator for enhanced hypoxia-dampened chemotherapy and NIR-II photothermal therapy.
KW - chemotherapy
KW - endogenous oxygenation
KW - hypoxia alleviation
KW - near-infrared second window (NIR-II) photothermal therapy
KW - porous platinum/gold core-shell nanoenzyme
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U2 - 10.1021/acsnano.2c02528
DO - 10.1021/acsnano.2c02528
M3 - Article
C2 - 35838683
AN - SCOPUS:85135573536
SN - 1936-0851
VL - 16
SP - 10711
EP - 10728
JO - ACS Nano
JF - ACS Nano
IS - 7
ER -