Abstract
Gut organoids are 3D cellular structures derived from adult or pluripotent stem cells, capable of closely replicating the physiological properties of the gut. These organoids serve as powerful tools for studying gut development and modeling the pathogenesis of intestinal diseases. This review provides an in-depth exploration of technological advancements and applications of gut organoids, with a focus on their construction methods. Additionally, the potential applications of gut organoids in disease modeling, microenvironmental simulation, and personalized medicine are summarized. This review aims to offer perspectives and directions for understanding the mechanisms of intestinal health and disease as well as for developing innovative therapeutic strategies.
| Original language | English |
|---|---|
| Article number | lnaf012 |
| Journal | Life Medicine |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1 Apr 2025 |
Keywords
- intestinal disease
- microenvironment
- organoid
- personalized medicine
- therapeutic strategy