TY - GEN
T1 - Air-puff OCE for assessment of mouse cornea in vivo
AU - Li, Jiasong
AU - Wang, Shang
AU - Singh, Manmohan
AU - Aglyamov, Salavat
AU - Emelianov, Stanislav
AU - Twa, Michael
AU - Larin, Kirill V.
PY - 2014
Y1 - 2014
N2 - We characterize the relaxation rates of deformations created by focused air puffs with the use of phasestabilized swept source optical coherence elastography (PhS-SSOCE) in tissue-mimicking gelatin phantoms of various concentrations and mouse corneas of different ages in vivo. The results indicate that gelatin of varying concentrations and corneas from different aged mice have different relaxation rates. In addition, the results show that phantoms with higher concentration gelatin and corneas of older mice have higher relaxation rates, which can be attributed to stiffer material. Because this method is non-contact, noninvasive, and utilizes a minimal force which induces a deformation on the scale of μm, this method can be used to study the biomechanical properties of sensitive tissues, such as the cornea.
AB - We characterize the relaxation rates of deformations created by focused air puffs with the use of phasestabilized swept source optical coherence elastography (PhS-SSOCE) in tissue-mimicking gelatin phantoms of various concentrations and mouse corneas of different ages in vivo. The results indicate that gelatin of varying concentrations and corneas from different aged mice have different relaxation rates. In addition, the results show that phantoms with higher concentration gelatin and corneas of older mice have higher relaxation rates, which can be attributed to stiffer material. Because this method is non-contact, noninvasive, and utilizes a minimal force which induces a deformation on the scale of μm, this method can be used to study the biomechanical properties of sensitive tissues, such as the cornea.
KW - Air puff
KW - Cornea
KW - Optical coherence elastography
KW - Relaxation rate
KW - Stiffness
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U2 - 10.1117/12.2042258
DO - 10.1117/12.2042258
M3 - Conference contribution
AN - SCOPUS:84896963866
SN - 9780819498434
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Ophthalmic Technologies XXIV
T2 - 24th Conference on Ophthalmic Technologies
Y2 - 1 February 2014 through 2 February 2014
ER -