Air-puff OCE for assessment of mouse cornea in vivo

Jiasong Li, Shang Wang, Manmohan Singh, Salavat Aglyamov, Stanislav Emelianov, Michael Twa, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations

Abstract

We characterize the relaxation rates of deformations created by focused air puffs with the use of phasestabilized swept source optical coherence elastography (PhS-SSOCE) in tissue-mimicking gelatin phantoms of various concentrations and mouse corneas of different ages in vivo. The results indicate that gelatin of varying concentrations and corneas from different aged mice have different relaxation rates. In addition, the results show that phantoms with higher concentration gelatin and corneas of older mice have higher relaxation rates, which can be attributed to stiffer material. Because this method is non-contact, noninvasive, and utilizes a minimal force which induces a deformation on the scale of μm, this method can be used to study the biomechanical properties of sensitive tissues, such as the cornea.

Original languageEnglish
Title of host publicationOphthalmic Technologies XXIV
DOIs
StatePublished - 2014
Event24th Conference on Ophthalmic Technologies - San Francisco, CA, United States
Duration: 1 Feb 20142 Feb 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8930
ISSN (Print)1605-7422

Conference

Conference24th Conference on Ophthalmic Technologies
Country/TerritoryUnited States
CitySan Francisco, CA
Period1/02/142/02/14

Keywords

  • Air puff
  • Cornea
  • Optical coherence elastography
  • Relaxation rate
  • Stiffness

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