@inproceedings{a9b857fe226d4fbe9f153d6aee03d396,
title = "An electrokinetically controlled microchip for studying binding interactions of nucleic acids with cells",
abstract = "This paper presents an electrokinetically controlled microfluidic chip that allows investigation of binding interactions between nucleic acids and target cells. The microchip consists of two microchambers for capture of cells using an integrated microweir structure and collection of DNA strands, respectively. The chambers are connected by a microchannel filled with agarose gel. In the chip, nucleic acids that interact with target cells are electrokinetically separated and isolated from the cells through the gel-filled channel for subsequent analysis. Experimental results demonstrate that our microchip can potentially be used for studying interactions of nucleic acids with target cells in practical biomedical applications.",
keywords = "MCF-7 cells, Microfluidic chip, aptamers, electrophoresis, nucleic acids",
author = "J. Kim and Hilton, {J. P.} and K. Yang and R. Pei and M. Stojanovic and Q. Lin",
year = "2013",
doi = "10.1109/Transducers.2013.6626986",
language = "English",
isbn = "9781467359818",
series = "2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013",
pages = "1190--1193",
booktitle = "2013 Transducers and Eurosensors XXVII",
note = "2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 ; Conference date: 16-06-2013 Through 20-06-2013",
}