TY - JOUR
T1 - Antimicrobial loading into and release from poly(ethylene glycol)/poly(acrylic acid) semi-interpenetrating hydrogels
AU - Wu, Yong
AU - Liang, Jing
AU - Horkay, Ferenc
AU - Libera, Matthew
N1 - Publisher Copyright:
© 2015 Wiley Periodicals, Inc.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Electrostatic interactions within a semi-interpenetrating network (semi-IPN) gel can control the postsynthesis loading, long-term retention, and subsequent release of small-molecule cationic antibiotics. Here, electrostatic charge is introduced into an otherwise neutral gel [poly(ethylene glycol) (PEG)] by physically entrapping high-molecular-weight poly(acrylic acid) (PAA). The network structure is characterized by small-angle neutron scattering. PEG/PAA semi-IPN gels absorb over 40 times more antibiotic than PAA-free PEG gels. Subsequent soaking in physiological buffer (pH 7.4; 0.15 M NaCl) releases the loaded antibiotics for periods as long as 30 days. The loaded gels elute antibiotics with diffusivities of 4.46 × 10-8 cm2/s (amikacin) and 2.08 × 10-8 cm2/s (colistin), which are two orders of magnitude less than those in pure PEG gels where diffusion is controlled purely by gel tortuosity. The release and hindered diffusion can be understood based on the partial shielding of the charged groups within the loaded gel, and they have a significant effect on the antimicrobial properties of these gels.
AB - Electrostatic interactions within a semi-interpenetrating network (semi-IPN) gel can control the postsynthesis loading, long-term retention, and subsequent release of small-molecule cationic antibiotics. Here, electrostatic charge is introduced into an otherwise neutral gel [poly(ethylene glycol) (PEG)] by physically entrapping high-molecular-weight poly(acrylic acid) (PAA). The network structure is characterized by small-angle neutron scattering. PEG/PAA semi-IPN gels absorb over 40 times more antibiotic than PAA-free PEG gels. Subsequent soaking in physiological buffer (pH 7.4; 0.15 M NaCl) releases the loaded antibiotics for periods as long as 30 days. The loaded gels elute antibiotics with diffusivities of 4.46 × 10-8 cm2/s (amikacin) and 2.08 × 10-8 cm2/s (colistin), which are two orders of magnitude less than those in pure PEG gels where diffusion is controlled purely by gel tortuosity. The release and hindered diffusion can be understood based on the partial shielding of the charged groups within the loaded gel, and they have a significant effect on the antimicrobial properties of these gels.
KW - diffusion
KW - hydrogels
KW - poly(ethylene glycol)
KW - self-assembly
KW - semi-interpenetrating network
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U2 - 10.1002/polb.23924
DO - 10.1002/polb.23924
M3 - Article
AN - SCOPUS:84955193507
SN - 0887-6266
VL - 54
SP - 64
EP - 72
JO - Journal of Polymer Science, Part B: Polymer Physics
JF - Journal of Polymer Science, Part B: Polymer Physics
IS - 1
ER -