Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK1 Antagonists

Gregory A. Reichard; Carmine Stengone; Sunil Paliwal; Ingrid Mergelsberg; Sapna Majmundar; Cheng Wang; Robert Tiberi; Andrew T. McPhail; John J. Piwinski; Neng Yang Shih

doi:10.1021/ol030104p

Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK₁ Antagonists

Gregory A. Reichard
, Carmine Stengone
, Sunil Paliwal
, Ingrid Mergelsberg
, Sapna Majmundar
, Cheng Wang
, Robert Tiberi
, Andrew T. McPhail
, John J. Piwinski
, Neng Yang Shih

Department of Chemistry and Chemical Biology

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

(Equation presented) A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.

Original language	English
Pages (from-to)	4249-4251
Number of pages	3
Journal	Organic Letters
Volume	5
Issue number	23
DOIs	https://doi.org/10.1021/ol030104p
State	Published - 13 Nov 2003

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10.1021/ol030104p

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title = "Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK1 Antagonists",

abstract = "(Equation presented) A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a {"}self-reproduction of the center of chirality{"} strategy is described.",

author = "Reichard, \{Gregory A.\} and Carmine Stengone and Sunil Paliwal and Ingrid Mergelsberg and Sapna Majmundar and Cheng Wang and Robert Tiberi and McPhail, \{Andrew T.\} and Piwinski, \{John J.\} and Shih, \{Neng Yang\}",

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language = "English",

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T1 - Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones

T2 - Potent NK1 Antagonists

AU - Reichard, Gregory A.

AU - Stengone, Carmine

AU - Paliwal, Sunil

AU - Mergelsberg, Ingrid

AU - Majmundar, Sapna

AU - Wang, Cheng

AU - Tiberi, Robert

AU - McPhail, Andrew T.

AU - Piwinski, John J.

AU - Shih, Neng Yang

PY - 2003/11/13

Y1 - 2003/11/13

N2 - (Equation presented) A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.

AB - (Equation presented) A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.

UR - https://www.scopus.com/pages/publications/10744221221

UR - https://www.scopus.com/pages/publications/10744221221#tab=citedBy

U2 - 10.1021/ol030104p

DO - 10.1021/ol030104p

M3 - Article

AN - SCOPUS:10744221221

SN - 1523-7060

VL - 5

SP - 4249

EP - 4251

JO - Organic Letters

JF - Organic Letters

IS - 23

ER -

Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK₁ Antagonists

Abstract

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