Bacteria responsive antibacterial surfaces for indwelling device infections

Christian Traba, Jun F. Liang

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Indwelling device infections now represent life-threatening circumstances as a result of the biofilms' tolerance to antibiotic treatments. Current antibiotic impregnation approaches through sustained antibiotic release have some unsolved problems which include short life-span, narrowed antibacterial spectrum, ineffectiveness towards resistant mutants, and the potential to hasten the antibiotic resistance process. In this study, bacteria responsive anti-biofilm surfaces were developed using bioactive peptides with proved activity to antibiotic resistant bacteria and biofilms. Resulting surfaces were stable under physiological conditions and in the presence of high concentrations of salts (0.5 M NaCl) and biomacromolcules (1.0% DNA and 2.0% alginate), and thus showed good biocompatibility to various tissue cells. However, lytic peptide immobilized surfaces could sense bacteria adhesion and kill attached bacteria effectively and specifically, so biofilms were unable to develop on the lytic peptide immobilized surfaces. Bacteria responsive catheters remained biofilm free for up to a week. Therefore, the bacteria responsive antibacterial surfaces developed in this study represent new opportunities for indwelling device infections.

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalJournal of Controlled Release
Volume198
DOIs
StatePublished - 28 Jan 2015

Keywords

  • Biofilms
  • Biomedical devices
  • Controlled release
  • Infections
  • Peptides
  • Responsible

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