Biodegradable Electrospun Nanofibrous Scaffolds for Bone Tissue Engineering

Aneela Anwar, Daniel Jerome Petrino, Nicole Van Alstine, Xiaojun Yu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Biodegradable nanocomposite scaffolds have been used for bone regeneration by serving as provisional template with optimal mechanical and biological properties analogous to native extracellular matrix (ECM). Their unique biomimicking structures aid in cell adhesion, differentiation, and proliferation with similar characteristics of the cells’ ECM. Researchers are currently faced with a roadblock on ways to develop emerging process techniques to make biodegradable nanocomposite scaffolds and imitate these in exact synthetic ECM environments. This chapter particularly focuses on the technique of electrospinning for fabricating synthetic bone substitute materials for promoting bone repair and regeneration.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Pages693-711
Number of pages19
DOIs
StatePublished - 2022

Publication series

NameMethods in Molecular Biology
Volume2394
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Biodegradation
  • Bone
  • Collector
  • Electrospinning
  • Nanocomposite
  • Nanofiber
  • Polymer
  • Regeneration
  • Scaffold
  • Tissue

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