TY - GEN
T1 - Bioprinted nanoparticles for tissue engineering
AU - Buyukhatipoglu, Kivilcim
AU - Chang, Robert
AU - Sun, Wei
AU - Clyne, Alisa Morss
PY - 2009
Y1 - 2009
N2 - Tissue engineering may require recreation of the complex, three-dimensional native tissue architecture. While bioprinting allows cell and bioactive factor deposition in a precise pattern, it remains difficult to manipulate and track cells and bioactive factors after printing. We now show that superparamagnetic nanoparticles can be printed in an alginate hydrogel or inside cells themselves with low cell toxicity. Both nanoparticles and cells loaded with nanoparticles can be moved within the alginate hydrogel using a low field magnet, and nanoparticles can be imaged within the three-dimensional structure by micro-computed tomography. These data suggest that nanoparticles may advance biomanufacturing capabilities.
AB - Tissue engineering may require recreation of the complex, three-dimensional native tissue architecture. While bioprinting allows cell and bioactive factor deposition in a precise pattern, it remains difficult to manipulate and track cells and bioactive factors after printing. We now show that superparamagnetic nanoparticles can be printed in an alginate hydrogel or inside cells themselves with low cell toxicity. Both nanoparticles and cells loaded with nanoparticles can be moved within the alginate hydrogel using a low field magnet, and nanoparticles can be imaged within the three-dimensional structure by micro-computed tomography. These data suggest that nanoparticles may advance biomanufacturing capabilities.
KW - Alginate
KW - Biomanufacturing
KW - Endothelial cells
KW - Superparamagnetic nanoparticles
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=77950821218&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950821218&partnerID=8YFLogxK
U2 - 10.1109/CIMSA.2009.5069956
DO - 10.1109/CIMSA.2009.5069956
M3 - Conference contribution
AN - SCOPUS:77950821218
SN - 9781424438204
T3 - 2009 IEEE International Conference on Computational Intelligence for Measurement Systems and Applications, CIMSA 2009
SP - 234
EP - 237
BT - 2009 IEEE International Conference on Computational Intelligence for Measurement Systems and Applications, CIMSA 2009
T2 - 2009 IEEE International Conference on Computational Intelligence for Measurement Systems and Applications, CIMSA 2009
Y2 - 11 May 2009 through 13 May 2009
ER -