Bioprinted nanoparticles for tissue engineering

Kivilcim Buyukhatipoglu, Robert Chang, Wei Sun, Alisa Morss Clyne

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Tissue engineering may require recreation of the complex, three-dimensional native tissue architecture. While bioprinting allows cell and bioactive factor deposition in a precise pattern, it remains difficult to manipulate and track cells and bioactive factors after printing. We now show that superparamagnetic nanoparticles can be printed in an alginate hydrogel or inside cells themselves with low cell toxicity. Both nanoparticles and cells loaded with nanoparticles can be moved within the alginate hydrogel using a low field magnet, and nanoparticles can be imaged within the three-dimensional structure by micro-computed tomography. These data suggest that nanoparticles may advance biomanufacturing capabilities.

Original languageEnglish
Title of host publication2009 IEEE International Conference on Computational Intelligence for Measurement Systems and Applications, CIMSA 2009
Pages234-237
Number of pages4
DOIs
StatePublished - 2009
Event2009 IEEE International Conference on Computational Intelligence for Measurement Systems and Applications, CIMSA 2009 - Hong Kong, China
Duration: 11 May 200913 May 2009

Publication series

Name2009 IEEE International Conference on Computational Intelligence for Measurement Systems and Applications, CIMSA 2009

Conference

Conference2009 IEEE International Conference on Computational Intelligence for Measurement Systems and Applications, CIMSA 2009
Country/TerritoryChina
CityHong Kong
Period11/05/0913/05/09

Keywords

  • Alginate
  • Biomanufacturing
  • Endothelial cells
  • Superparamagnetic nanoparticles
  • Tissue engineering

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