Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip

J. E. Snyder, Q. Hamid, C. Wang, R. Chang, K. Emami, H. Wu, W. Sun

Research output: Contribution to journalArticlepeer-review

181 Scopus citations

Abstract

The objective of this paper is to introduce a novel cell printing and microfluidic system to serve as a portable ground model for the study of drug conversion and radiation protection of living liver tissue analogs. The system is applied to study behavior in ground models of space stress, particularly radiation. A microfluidic environment is engineered by two cell types to prepare an improved higher fidelity in vitro micro-liver tissue analog. Cell-laden Matrigel printing and microfluidic chips were used to test radiation shielding to liver cells by the pro-drug amifostine. In this work, the sealed microfluidic chip regulates three variables of interest: radiation exposure, anti-radiation drug treatment and single- or dual-tissue culture environments. This application is intended to obtain a scientific understanding of the response of the multi-cellular biological system for long-term manned space exploration, disease models and biosensors.

Original languageEnglish
Article number034112
JournalBiofabrication
Volume3
Issue number3
DOIs
StatePublished - Sep 2011

Fingerprint

Dive into the research topics of 'Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip'. Together they form a unique fingerprint.

Cite this