TY - CHAP
T1 - Bioreactors for evaluating cell infiltration and tissue formation in biomaterials
AU - Junka, R. A.
AU - Daly, L. E.
AU - Yu, X.
PY - 2012/12
Y1 - 2012/12
N2 - Bioreactors allow for engineering complex three-dimensional tissues in vitro as well as understanding and controlling tissue assembly and function on a cellular level. There are numerous designs, configurations, and conditions that have been applied for cell and tissue culture of liver, heart, bone, cartilage, ligaments, blood vessels and other tissues. Computational fluid dynamics as well as other monitoring and sensing technologies can further optimize the mechanical, electrical and chemical conditions used in bioreactors. This chapter is a brief summary of technologies and conditions tested in bioreactor systems for cell infiltration and tissue formation, as well as a review of critical shortcomings and future developments that would allow for development of clinically relevant tissues.
AB - Bioreactors allow for engineering complex three-dimensional tissues in vitro as well as understanding and controlling tissue assembly and function on a cellular level. There are numerous designs, configurations, and conditions that have been applied for cell and tissue culture of liver, heart, bone, cartilage, ligaments, blood vessels and other tissues. Computational fluid dynamics as well as other monitoring and sensing technologies can further optimize the mechanical, electrical and chemical conditions used in bioreactors. This chapter is a brief summary of technologies and conditions tested in bioreactor systems for cell infiltration and tissue formation, as well as a review of critical shortcomings and future developments that would allow for development of clinically relevant tissues.
KW - 3D tissue engineering
KW - Bioreactors
KW - Cell seeding
KW - Computational fluid dynamics (CFD)
UR - http://www.scopus.com/inward/record.url?scp=84904235399&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904235399&partnerID=8YFLogxK
U2 - 10.1533/9780857093684.138
DO - 10.1533/9780857093684.138
M3 - Chapter
AN - SCOPUS:84904235399
SN - 9781845698102
SP - 138
EP - 181
BT - Characterization of Biomaterials
ER -