Bioreactors for evaluating cell infiltration and tissue formation in biomaterials

R. A. Junka, L. E. Daly, X. Yu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Bioreactors allow for engineering complex three-dimensional tissues in vitro as well as understanding and controlling tissue assembly and function on a cellular level. There are numerous designs, configurations, and conditions that have been applied for cell and tissue culture of liver, heart, bone, cartilage, ligaments, blood vessels and other tissues. Computational fluid dynamics as well as other monitoring and sensing technologies can further optimize the mechanical, electrical and chemical conditions used in bioreactors. This chapter is a brief summary of technologies and conditions tested in bioreactor systems for cell infiltration and tissue formation, as well as a review of critical shortcomings and future developments that would allow for development of clinically relevant tissues.

Original languageEnglish
Title of host publicationCharacterization of Biomaterials
Pages138-181
Number of pages44
DOIs
StatePublished - Dec 2012

Keywords

  • 3D tissue engineering
  • Bioreactors
  • Cell seeding
  • Computational fluid dynamics (CFD)

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