Biosynthetic studies of platencin

Kithsiri Herath; Athula B. Attygalle; Sheo B. Singh

doi:10.1016/j.tetlet.2008.07.106

Biosynthetic studies of platencin

Kithsiri Herath, Athula B. Attygalle, Sheo B. Singh

Department of Chemistry and Chemical Biology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Platensimycin and platencin are two potent and novel antibiotics that exert their antibiotic activities: by inhibiting condensing enzymes of bacterial fatty acid biosynthesis. Both compounds are composed of two structural units; a common 3-amino-2,4-dihydroxybenzoic acid moiety and different C-17 polycyclic enone acid moiety. The latter moiety of each compound is biosynthesized by the non-mevalonate MEP pathway, whereas the former moiety is made from by the TCA cycle and PEP by condensation of 4+3 carbon units. Herein, the details of biosynthesis of platencin are described.

Original language	English
Pages (from-to)	5755-5758
Number of pages	4
Journal	Tetrahedron Letters
Volume	49
Issue number	40
DOIs	https://doi.org/10.1016/j.tetlet.2008.07.106
State	Published - 29 Sep 2008

Access to Document

10.1016/j.tetlet.2008.07.106

Cite this

@article{6b63a9409b574f388ab129f4c4364e60,

title = "Biosynthetic studies of platencin",

abstract = "Platensimycin and platencin are two potent and novel antibiotics that exert their antibiotic activities: by inhibiting condensing enzymes of bacterial fatty acid biosynthesis. Both compounds are composed of two structural units; a common 3-amino-2,4-dihydroxybenzoic acid moiety and different C-17 polycyclic enone acid moiety. The latter moiety of each compound is biosynthesized by the non-mevalonate MEP pathway, whereas the former moiety is made from by the TCA cycle and PEP by condensation of 4+3 carbon units. Herein, the details of biosynthesis of platencin are described.",

author = "Kithsiri Herath and Attygalle, {Athula B.} and Singh, {Sheo B.}",

year = "2008",

month = sep,

day = "29",

doi = "10.1016/j.tetlet.2008.07.106",

language = "English",

volume = "49",

pages = "5755--5758",

number = "40",

}

TY - JOUR

T1 - Biosynthetic studies of platencin

AU - Herath, Kithsiri

AU - Attygalle, Athula B.

AU - Singh, Sheo B.

PY - 2008/9/29

Y1 - 2008/9/29

N2 - Platensimycin and platencin are two potent and novel antibiotics that exert their antibiotic activities: by inhibiting condensing enzymes of bacterial fatty acid biosynthesis. Both compounds are composed of two structural units; a common 3-amino-2,4-dihydroxybenzoic acid moiety and different C-17 polycyclic enone acid moiety. The latter moiety of each compound is biosynthesized by the non-mevalonate MEP pathway, whereas the former moiety is made from by the TCA cycle and PEP by condensation of 4+3 carbon units. Herein, the details of biosynthesis of platencin are described.

AB - Platensimycin and platencin are two potent and novel antibiotics that exert their antibiotic activities: by inhibiting condensing enzymes of bacterial fatty acid biosynthesis. Both compounds are composed of two structural units; a common 3-amino-2,4-dihydroxybenzoic acid moiety and different C-17 polycyclic enone acid moiety. The latter moiety of each compound is biosynthesized by the non-mevalonate MEP pathway, whereas the former moiety is made from by the TCA cycle and PEP by condensation of 4+3 carbon units. Herein, the details of biosynthesis of platencin are described.

UR - http://www.scopus.com/inward/record.url?scp=49549088132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49549088132&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2008.07.106

DO - 10.1016/j.tetlet.2008.07.106

M3 - Article

AN - SCOPUS:49549088132

SN - 0040-4039

VL - 49

SP - 5755

EP - 5758

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 40

ER -

Biosynthetic studies of platencin

Abstract

Access to Document

Other files and links

Fingerprint

Cite this