Biosynthetic studies of platencin

Kithsiri Herath; Athula B. Attygalle; Sheo B. Singh

doi:10.1016/j.tetlet.2008.07.106

Biosynthetic studies of platencin

Kithsiri Herath, Athula B. Attygalle, Sheo B. Singh

Department of Chemistry and Chemical Biology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Platensimycin and platencin are two potent and novel antibiotics that exert their antibiotic activities: by inhibiting condensing enzymes of bacterial fatty acid biosynthesis. Both compounds are composed of two structural units; a common 3-amino-2,4-dihydroxybenzoic acid moiety and different C-17 polycyclic enone acid moiety. The latter moiety of each compound is biosynthesized by the non-mevalonate MEP pathway, whereas the former moiety is made from by the TCA cycle and PEP by condensation of 4+3 carbon units. Herein, the details of biosynthesis of platencin are described.

Original language	English
Pages (from-to)	5755-5758
Number of pages	4
Journal	Tetrahedron Letters
Volume	49
Issue number	40
DOIs	https://doi.org/10.1016/j.tetlet.2008.07.106
State	Published - 29 Sep 2008

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AU - Herath, Kithsiri

AU - Attygalle, Athula B.

AU - Singh, Sheo B.

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N2 - Platensimycin and platencin are two potent and novel antibiotics that exert their antibiotic activities: by inhibiting condensing enzymes of bacterial fatty acid biosynthesis. Both compounds are composed of two structural units; a common 3-amino-2,4-dihydroxybenzoic acid moiety and different C-17 polycyclic enone acid moiety. The latter moiety of each compound is biosynthesized by the non-mevalonate MEP pathway, whereas the former moiety is made from by the TCA cycle and PEP by condensation of 4+3 carbon units. Herein, the details of biosynthesis of platencin are described.

AB - Platensimycin and platencin are two potent and novel antibiotics that exert their antibiotic activities: by inhibiting condensing enzymes of bacterial fatty acid biosynthesis. Both compounds are composed of two structural units; a common 3-amino-2,4-dihydroxybenzoic acid moiety and different C-17 polycyclic enone acid moiety. The latter moiety of each compound is biosynthesized by the non-mevalonate MEP pathway, whereas the former moiety is made from by the TCA cycle and PEP by condensation of 4+3 carbon units. Herein, the details of biosynthesis of platencin are described.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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Biosynthetic studies of platencin

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