TY - JOUR
T1 - Camouflaged Gold Nanodendrites Enable Synergistic Photodynamic Therapy and NIR Biowindow II Photothermal Therapy and Multimodal Imaging
AU - Sun, Jingyu
AU - Wang, Jinping
AU - Hu, Wei
AU - Wang, Yuhao
AU - Chou, Tsengming
AU - Zhang, Qiang
AU - Zhang, Beilu
AU - Yu, Zhengqian
AU - Yang, Yamin
AU - Ren, Lei
AU - Wang, Hongjun
N1 - Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/3/10
Y1 - 2021/3/10
N2 - Gold nanodendrite (AuND)-based nanotheranostic agents with versatile capabilities were fabricated by optimizing the geometrical configurations (dendrite length and density) of AuND to achieve localized surface plasmon resonance (LSPR) in near-infrared biowindow II (NIR-II), and then subsequently functionalizing with a mitochondria-targeting compound (triphenylphosphonium, TPP), loading with an NIR-photosensitizer (indocyanine green, ICG) and coating with the macrophage cell membrane (MCM) to trap ICG within AuND and selectively interact with MDA-MB-231 cells. The novel AuND-TPP-ICG@MCM system enabled the integration of multimodal fluorescence/photoacoustic/surface-enhanced Raman imaging with synergistic therapies of NIR-II photothermal therapy and NIR-I photodynamic therapy for cancer treatment. Enhanced hyperthermia and elevated production of reactive oxygen species within the tumors via MCM coating and mitochondria targeting afforded a synergistic efficacy for tumor eradication with limited side effects. The demonstrated biocompatibility, multi-imaging capability, and high therapeutic efficiency under NIR laser irradiation indicate the potentials of this multifunctional nanotheranostic platform for clinical utility in cancer therapy.
AB - Gold nanodendrite (AuND)-based nanotheranostic agents with versatile capabilities were fabricated by optimizing the geometrical configurations (dendrite length and density) of AuND to achieve localized surface plasmon resonance (LSPR) in near-infrared biowindow II (NIR-II), and then subsequently functionalizing with a mitochondria-targeting compound (triphenylphosphonium, TPP), loading with an NIR-photosensitizer (indocyanine green, ICG) and coating with the macrophage cell membrane (MCM) to trap ICG within AuND and selectively interact with MDA-MB-231 cells. The novel AuND-TPP-ICG@MCM system enabled the integration of multimodal fluorescence/photoacoustic/surface-enhanced Raman imaging with synergistic therapies of NIR-II photothermal therapy and NIR-I photodynamic therapy for cancer treatment. Enhanced hyperthermia and elevated production of reactive oxygen species within the tumors via MCM coating and mitochondria targeting afforded a synergistic efficacy for tumor eradication with limited side effects. The demonstrated biocompatibility, multi-imaging capability, and high therapeutic efficiency under NIR laser irradiation indicate the potentials of this multifunctional nanotheranostic platform for clinical utility in cancer therapy.
KW - Raman imaging
KW - gold nanodendrites
KW - photoacoustic imaging
KW - photodynamic therapy
KW - second near-infrared photothermal therapy
UR - https://www.scopus.com/pages/publications/85102965256
UR - https://www.scopus.com/pages/publications/85102965256#tab=citedBy
U2 - 10.1021/acsami.1c01238
DO - 10.1021/acsami.1c01238
M3 - Article
C2 - 33646767
AN - SCOPUS:85102965256
SN - 1944-8244
VL - 13
SP - 10778
EP - 10795
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 9
ER -
