Carbon nanotube chemiresistor for wireless pH sensing

Pingping Gou; Nadine D. Kraut; Ian M. Feigel; Hao Bai; Gregory J. Morgan; Yanan Chen; Yifan Tang; Kara Bocan; Joshua Stachel; Lee Berger; Marlin Mickle; Ervin SejdiĆ; Alexander Star

doi:10.1038/srep04468

Carbon nanotube chemiresistor for wireless pH sensing

Pingping Gou, Nadine D. Kraut, Ian M. Feigel, Hao Bai, Gregory J. Morgan, Yanan Chen, Yifan Tang, Kara Bocan, Joshua Stachel, Lee Berger, Marlin Mickle, Ervin SejdiĆ, Alexander Star

School of Humanities, Arts and Social Sciences

University of Pittsburgh

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

The ability to accurately measure real-time pH fluctuations in-vivo could be highly advantageous. Early detection and potential prevention of bacteria colonization of surgical implants can be accomplished by monitoring associated acidosis. However, conventional glass membrane or ion-selective field-effect transistor (ISFET) pH sensing technologies both require a reference electrode which may suffer from leakage of electrolytes and potential contamination. Herein, we describe a solid-state sensor based on oxidized single-walled carbon nanotubes (ox-SWNTs) functionalized with the conductive polymer poly(1-aminoanthracene) (PAA). This device had a Nernstian response over a wide pH range (2-12) and retained sensitivity over 120 days. The sensor was also attached to a passively-powered radio-frequency identification (RFID) tag which transmits pH data through simulated skin. This battery-less, reference electrode free, wirelessly transmitting sensor platform shows potential for biomedical applications as an implantable sensor, adjacent to surgical implants detecting for infection.

Original language	English
Article number	4468
Journal	Scientific Reports
Volume	4
DOIs	https://doi.org/10.1038/srep04468
State	Published - 26 Mar 2014

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title = "Carbon nanotube chemiresistor for wireless pH sensing",

abstract = "The ability to accurately measure real-time pH fluctuations in-vivo could be highly advantageous. Early detection and potential prevention of bacteria colonization of surgical implants can be accomplished by monitoring associated acidosis. However, conventional glass membrane or ion-selective field-effect transistor (ISFET) pH sensing technologies both require a reference electrode which may suffer from leakage of electrolytes and potential contamination. Herein, we describe a solid-state sensor based on oxidized single-walled carbon nanotubes (ox-SWNTs) functionalized with the conductive polymer poly(1-aminoanthracene) (PAA). This device had a Nernstian response over a wide pH range (2-12) and retained sensitivity over 120 days. The sensor was also attached to a passively-powered radio-frequency identification (RFID) tag which transmits pH data through simulated skin. This battery-less, reference electrode free, wirelessly transmitting sensor platform shows potential for biomedical applications as an implantable sensor, adjacent to surgical implants detecting for infection.",

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AU - Gou, Pingping

AU - Kraut, Nadine D.

AU - Feigel, Ian M.

AU - Bai, Hao

AU - Morgan, Gregory J.

AU - Chen, Yanan

AU - Tang, Yifan

AU - Bocan, Kara

AU - Stachel, Joshua

AU - Berger, Lee

AU - Mickle, Marlin

AU - SejdiĆ, Ervin

AU - Star, Alexander

PY - 2014/3/26

Y1 - 2014/3/26

N2 - The ability to accurately measure real-time pH fluctuations in-vivo could be highly advantageous. Early detection and potential prevention of bacteria colonization of surgical implants can be accomplished by monitoring associated acidosis. However, conventional glass membrane or ion-selective field-effect transistor (ISFET) pH sensing technologies both require a reference electrode which may suffer from leakage of electrolytes and potential contamination. Herein, we describe a solid-state sensor based on oxidized single-walled carbon nanotubes (ox-SWNTs) functionalized with the conductive polymer poly(1-aminoanthracene) (PAA). This device had a Nernstian response over a wide pH range (2-12) and retained sensitivity over 120 days. The sensor was also attached to a passively-powered radio-frequency identification (RFID) tag which transmits pH data through simulated skin. This battery-less, reference electrode free, wirelessly transmitting sensor platform shows potential for biomedical applications as an implantable sensor, adjacent to surgical implants detecting for infection.

AB - The ability to accurately measure real-time pH fluctuations in-vivo could be highly advantageous. Early detection and potential prevention of bacteria colonization of surgical implants can be accomplished by monitoring associated acidosis. However, conventional glass membrane or ion-selective field-effect transistor (ISFET) pH sensing technologies both require a reference electrode which may suffer from leakage of electrolytes and potential contamination. Herein, we describe a solid-state sensor based on oxidized single-walled carbon nanotubes (ox-SWNTs) functionalized with the conductive polymer poly(1-aminoanthracene) (PAA). This device had a Nernstian response over a wide pH range (2-12) and retained sensitivity over 120 days. The sensor was also attached to a passively-powered radio-frequency identification (RFID) tag which transmits pH data through simulated skin. This battery-less, reference electrode free, wirelessly transmitting sensor platform shows potential for biomedical applications as an implantable sensor, adjacent to surgical implants detecting for infection.

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Carbon nanotube chemiresistor for wireless pH sensing

Abstract

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