Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes

Chen Wu, Zhaolong Han, Shang Wang, Jiasong Li, Manmohan Singh, Chih Hao Liu, Salavat Aglyamov, Stanislav Emelianov, Fabrice Manns, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this study, we utilize a confocal ultrasound and phase-sensitive optical coherence elastography (OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in intact rabbit eyes in situ. Lowamplitude elastic deformations, induced on the surface of the lens by localized acoustic radiation force, were measured using phase-sensitive OCT. The results demonstrate that the displacements induced in young rabbit lenses are significantly larger than those in the mature lenses. Temporal analyses of the elastic waves are also demonstrated significant difference between young and old lenses, indicating that the stiffness of lens increases with the age. These results demonstrate possibility of OCE for completely noninvasive analysis and quantification of lens biomechanical properties, which could be used in many clinical and basic science applications such as surgeries and studies on lens physiology and function.

Original languageEnglish
Title of host publicationOphthalmic Technologies XXV
EditorsArthur Ho, Fabrice Manns, Per G. Soderberg
ISBN (Electronic)9781628413977
DOIs
StatePublished - 2015
Event25th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: 7 Feb 20158 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9307
ISSN (Print)1605-7422

Conference

Conference25th Conference on Ophthalmic Technologies
Country/TerritoryUnited States
CitySan Francisco
Period7/02/158/02/15

Keywords

  • acoustic radiation
  • biomechanical properties
  • crystalline lens
  • force
  • optical coherence elastography (OCE)

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