TY - JOUR
T1 - Combinatorial chemistry in insects
T2 - A library of defensive macrocyclic polyamines
AU - Schröder, Frank C.
AU - Farmer, Jay J.
AU - Attygalle, Athula B.
AU - Smedley, Scott R.
AU - Eisner, Thomas
AU - Meinwald, Jerrold
PY - 1998/7/17
Y1 - 1998/7/17
N2 - The pupal defensive secretion of the coccinellid beetle Epilachna borealis is composed principally of a combinatorial library of macrocyclic polyamines. These compounds constitute a previously unrecognized family of natural products, characterized by extremely large-ring lactonic structures derived from a small set of (2-hydroxyethylamino)alkanoic acids. The combinatorial assembly of these simple building blocks generates a high degree of structural diversity, which is further increased by slow, spontaneous intramolecular rearrangement of the macrocycles.
AB - The pupal defensive secretion of the coccinellid beetle Epilachna borealis is composed principally of a combinatorial library of macrocyclic polyamines. These compounds constitute a previously unrecognized family of natural products, characterized by extremely large-ring lactonic structures derived from a small set of (2-hydroxyethylamino)alkanoic acids. The combinatorial assembly of these simple building blocks generates a high degree of structural diversity, which is further increased by slow, spontaneous intramolecular rearrangement of the macrocycles.
UR - https://www.scopus.com/pages/publications/0040364379
UR - https://www.scopus.com/pages/publications/0040364379#tab=citedBy
U2 - 10.1126/science.281.5375.428
DO - 10.1126/science.281.5375.428
M3 - Article
C2 - 9665888
AN - SCOPUS:0040364379
SN - 0036-8075
VL - 281
SP - 428
EP - 431
JO - Science
JF - Science
IS - 5375
ER -