Combining a focused air-puff system with phase-sensitive optical coherence tomography for the detection of soft-tissue tumors based on elasticity measurement

  • Shang Wang
  • , Jiasong Li
  • , Srilatha Vantipalli
  • , Ravi Kiran Manapuram
  • , Davis R. Ingram
  • , Michael D. Twa
  • , Alexander J. Lazar
  • , Dina C. Lev
  • , Raphael E. Pollock
  • , Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We combine a focused air-puff system with phase-sensitive optical coherence tomography (PhS-OCT) to measure the elasticity of soft tissues. Surface waves (SWs) on soft tissues are induced by a low-pressure, short-duration air stream from an air-puff system and measured using a high-sensitivity PhS-OCT imaging system. Young?s modulus of soft tissues can be quantified based on the group velocity of SWs. To precisely control the excitation pressure, the air-puff system was characterized with a high-resolution analog pressure transducer. We studied the feasibility of this method for the non-contact detection of soft-tissue tumors. Ex vivo human fat and myxoma were used for these pilot experiments. Results demonstrate that this optical non-contact technique can be used to differentiate soft-tissue tumors from normal tissues based on measurements of their elasticity.

Original languageEnglish
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
DOIs
StatePublished - 2013
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII - San Francisco, CA, United States
Duration: 4 Feb 20136 Feb 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8571
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
Country/TerritoryUnited States
CitySan Francisco, CA
Period4/02/136/02/13

Keywords

  • Young's modulus
  • air-puff system
  • optical coherence tomography
  • phase-resolved method
  • soft-tissue tumors
  • surface waves

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