Controlling epileptiform activity with organic electronic ion pumps

Adam Williamson; Jonathan Rivnay; Loïg Kergoat; Amanda Jonsson; Sahika Inal; Ilke Uguz; Marc Ferro; Anton Ivanov; Theresia Arbring Sjöström; Daniel T. Simon; Magnus Berggren; George G. Malliaras; Christophe Bernard

doi:10.1002/adma.201500482

Controlling epileptiform activity with organic electronic ion pumps

Adam Williamson
, Jonathan Rivnay
, Loïg Kergoat
, Amanda Jonsson
, Sahika Inal
, Ilke Uguz
, Marc Ferro
, Anton Ivanov
, Theresia Arbring Sjöström
, Daniel T. Simon
, Magnus Berggren
, George G. Malliaras
, Christophe Bernard

Department of Biomedical Engineering

Linköping University

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

Original language	English
Pages (from-to)	3138-3144
Number of pages	7
Journal	Advanced Materials
Volume	27
Issue number	20
DOIs	https://doi.org/10.1002/adma.201500482
State	Published - 1 May 2015

Keywords

neuroengineering
organic bioelectronics
organic electronic ion pumps
PEDOT:PSS

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10.1002/adma.201500482

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title = "Controlling epileptiform activity with organic electronic ion pumps",

abstract = "In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.",

keywords = "neuroengineering, organic bioelectronics, organic electronic ion pumps, PEDOT:PSS",

author = "Adam Williamson and Jonathan Rivnay and Lo{\"i}g Kergoat and Amanda Jonsson and Sahika Inal and Ilke Uguz and Marc Ferro and Anton Ivanov and Sj{\"o}str{\"o}m, \{Theresia Arbring\} and Simon, \{Daniel T.\} and Magnus Berggren and Malliaras, \{George G.\} and Christophe Bernard",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

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doi = "10.1002/adma.201500482",

language = "English",

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T1 - Controlling epileptiform activity with organic electronic ion pumps

AU - Williamson, Adam

AU - Rivnay, Jonathan

AU - Kergoat, Loïg

AU - Jonsson, Amanda

AU - Inal, Sahika

AU - Uguz, Ilke

AU - Ferro, Marc

AU - Ivanov, Anton

AU - Sjöström, Theresia Arbring

AU - Simon, Daniel T.

AU - Berggren, Magnus

AU - Malliaras, George G.

AU - Bernard, Christophe

PY - 2015/5/1

Y1 - 2015/5/1

N2 - In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

AB - In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

KW - neuroengineering

KW - organic bioelectronics

KW - organic electronic ion pumps

KW - PEDOT:PSS

UR - https://www.scopus.com/pages/publications/84929579888

UR - https://www.scopus.com/pages/publications/84929579888#tab=citedBy

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SN - 0935-9648

VL - 27

SP - 3138

EP - 3144

JO - Advanced Materials

JF - Advanced Materials

IS - 20

ER -

Controlling epileptiform activity with organic electronic ion pumps

Abstract

Keywords

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