Copper-catalyzed direct secondary and tertiary C-H alkylation of azoles through a heteroarene-amine-aldehyde/ketone coupling reaction

Dipak D. Vachhani, Abhishek Sharma, Erik Van Der Eycken

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Coupling the strangers: A copper-catalyzed three-component heteroarene-amine-aldehyde/ketone coupling affords a novel approach to the hitherto difficult direct secondary/tertiary C-H alkylation of azoles. This simple method allows the facile installation of diversely substituted, branched and nitrogen-containing alkyl or alkaloid side chains on the azole moiety by using readily available starting materials (see scheme).

Original languageEnglish
Pages (from-to)2547-2550
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number9
DOIs
StatePublished - 25 Feb 2013

Keywords

  • C-H activation
  • alkylation
  • azoles
  • copper
  • multicomponent reactions

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