TY - JOUR
T1 - Copper-catalyzed direct secondary and tertiary C-H alkylation of azoles through a heteroarene-amine-aldehyde/ketone coupling reaction
AU - Vachhani, Dipak D.
AU - Sharma, Abhishek
AU - Van Der Eycken, Erik
PY - 2013/2/25
Y1 - 2013/2/25
N2 - Coupling the strangers: A copper-catalyzed three-component heteroarene-amine-aldehyde/ketone coupling affords a novel approach to the hitherto difficult direct secondary/tertiary C-H alkylation of azoles. This simple method allows the facile installation of diversely substituted, branched and nitrogen-containing alkyl or alkaloid side chains on the azole moiety by using readily available starting materials (see scheme).
AB - Coupling the strangers: A copper-catalyzed three-component heteroarene-amine-aldehyde/ketone coupling affords a novel approach to the hitherto difficult direct secondary/tertiary C-H alkylation of azoles. This simple method allows the facile installation of diversely substituted, branched and nitrogen-containing alkyl or alkaloid side chains on the azole moiety by using readily available starting materials (see scheme).
KW - C-H activation
KW - alkylation
KW - azoles
KW - copper
KW - multicomponent reactions
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U2 - 10.1002/anie.201209312
DO - 10.1002/anie.201209312
M3 - Article
C2 - 23341157
AN - SCOPUS:84874278605
SN - 1433-7851
VL - 52
SP - 2547
EP - 2550
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 9
ER -