Abstract
A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.
Original language | English |
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Pages (from-to) | 3896-3899 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 15 |
Issue number | 17 |
DOIs | |
State | Published - 1 Sep 2005 |