Cyclic urea derivatives as potent NK1 selective antagonists

Ho Jane Shue, Xiao Chen, Neng Yang Shih, David J. Blythin, Sunil Paliwal, Ling Lin, Danlin Gu, John H. Schwerdt, Sapna Shah, Gregory A. Reichard, John J. Piwinski, Ruth A. Duffy, Jean E. Lachowicz, Vicki L. Coffin, Fei Liu, Amin A. Nomeir, Cynthia A. Morgan, Geoffrey B. Varty

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.

Original languageEnglish
Pages (from-to)3896-3899
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number17
DOIs
StatePublished - 1 Sep 2005

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