Cyclic urea derivatives as potent NK1 selective antagonists

Ho Jane Shue; Xiao Chen; Neng Yang Shih; David J. Blythin; Sunil Paliwal; Ling Lin; Danlin Gu; John H. Schwerdt; Sapna Shah; Gregory A. Reichard; John J. Piwinski; Ruth A. Duffy; Jean E. Lachowicz; Vicki L. Coffin; Fei Liu; Amin A. Nomeir; Cynthia A. Morgan; Geoffrey B. Varty

doi:10.1016/j.bmcl.2005.05.111

Cyclic urea derivatives as potent NK₁ selective antagonists

Ho Jane Shue, Xiao Chen, Neng Yang Shih, David J. Blythin, Sunil Paliwal, Ling Lin, Danlin Gu, John H. Schwerdt, Sapna Shah, Gregory A. Reichard, John J. Piwinski, Ruth A. Duffy, Jean E. Lachowicz, Vicki L. Coffin, Fei Liu, Amin A. Nomeir, Cynthia A. Morgan, Geoffrey B. Varty

Department of Chemistry and Chemical Biology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK₁ receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.

Original language	English
Pages (from-to)	3896-3899
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	17
DOIs	https://doi.org/10.1016/j.bmcl.2005.05.111
State	Published - 1 Sep 2005

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Shue, H. J., Chen, X., Shih, N. Y., Blythin, D. J., Paliwal, S., Lin, L., Gu, D., Schwerdt, J. H., Shah, S., Reichard, G. A., Piwinski, J. J., Duffy, R. A., Lachowicz, J. E., Coffin, V. L., Liu, F., Nomeir, A. A., Morgan, C. A., & Varty, G. B. (2005). Cyclic urea derivatives as potent NK₁ selective antagonists. Bioorganic and Medicinal Chemistry Letters, 15(17), 3896-3899. https://doi.org/10.1016/j.bmcl.2005.05.111

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title = "Cyclic urea derivatives as potent NK1 selective antagonists",

abstract = "A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.",

author = "Shue, \{Ho Jane\} and Xiao Chen and Shih, \{Neng Yang\} and Blythin, \{David J.\} and Sunil Paliwal and Ling Lin and Danlin Gu and Schwerdt, \{John H.\} and Sapna Shah and Reichard, \{Gregory A.\} and Piwinski, \{John J.\} and Duffy, \{Ruth A.\} and Lachowicz, \{Jean E.\} and Coffin, \{Vicki L.\} and Fei Liu and Nomeir, \{Amin A.\} and Morgan, \{Cynthia A.\} and Varty, \{Geoffrey B.\}",

year = "2005",

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doi = "10.1016/j.bmcl.2005.05.111",

language = "English",

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Shue, HJ, Chen, X, Shih, NY, Blythin, DJ, Paliwal, S, Lin, L, Gu, D, Schwerdt, JH, Shah, S, Reichard, GA, Piwinski, JJ, Duffy, RA, Lachowicz, JE, Coffin, VL, Liu, F, Nomeir, AA, Morgan, CA & Varty, GB 2005, 'Cyclic urea derivatives as potent NK₁ selective antagonists', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 17, pp. 3896-3899. https://doi.org/10.1016/j.bmcl.2005.05.111

TY - JOUR

T1 - Cyclic urea derivatives as potent NK1 selective antagonists

AU - Shue, Ho Jane

AU - Chen, Xiao

AU - Shih, Neng Yang

AU - Blythin, David J.

AU - Paliwal, Sunil

AU - Lin, Ling

AU - Gu, Danlin

AU - Schwerdt, John H.

AU - Shah, Sapna

AU - Reichard, Gregory A.

AU - Piwinski, John J.

AU - Duffy, Ruth A.

AU - Lachowicz, Jean E.

AU - Coffin, Vicki L.

AU - Liu, Fei

AU - Nomeir, Amin A.

AU - Morgan, Cynthia A.

AU - Varty, Geoffrey B.

PY - 2005/9/1

Y1 - 2005/9/1

N2 - A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.

AB - A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.

UR - https://www.scopus.com/pages/publications/23244466620

UR - https://www.scopus.com/inward/citedby.url?scp=23244466620&partnerID=8YFLogxK

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M3 - Article

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AN - SCOPUS:23244466620

SN - 0960-894X

VL - 15

SP - 3896

EP - 3899

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 17

ER -

Cyclic urea derivatives as potent NK₁ selective antagonists

Abstract

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