TY - GEN
T1 - Delivery of liquid micro-volumes into targeted regions of the lung
AU - Kim, J.
AU - O'Neill, J. D.
AU - Dorrello, N. V.
AU - Bacchetta, M. D.
AU - Vunjak-Novakovic, G.
N1 - Publisher Copyright:
© 15CBMS-0001.
PY - 2015
Y1 - 2015
N2 - The ability to deliver drugs to specific sites in the lung could radically improve therapeutic outcomes of many lung diseases, including cystic fibrosis, severe bronchopneumonia, and lung cancer. Unfortunately, conventional methods for pulmonary drug administration lack the ability for precise, localized drug delivery to target regions, and typically induce systemic side effects. Here, we describe a more controlled approach to deliver soluble drug reagents in the form of microliter-volume liquid plugs to desired lung regions via air ventilation. Using this approach, exact drug doses can be effectively delivered to the targeted pathologic lung regions to increase the drug efficacy.
AB - The ability to deliver drugs to specific sites in the lung could radically improve therapeutic outcomes of many lung diseases, including cystic fibrosis, severe bronchopneumonia, and lung cancer. Unfortunately, conventional methods for pulmonary drug administration lack the ability for precise, localized drug delivery to target regions, and typically induce systemic side effects. Here, we describe a more controlled approach to deliver soluble drug reagents in the form of microliter-volume liquid plugs to desired lung regions via air ventilation. Using this approach, exact drug doses can be effectively delivered to the targeted pathologic lung regions to increase the drug efficacy.
KW - Liquid instillation
KW - Lung disease
KW - Pulmonary drug delivery
UR - http://www.scopus.com/inward/record.url?scp=84983320435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983320435&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84983320435
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 2138
EP - 2140
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Y2 - 25 October 2015 through 29 October 2015
ER -
