TY - JOUR
T1 - Design and development of a novel biostretch apparatus for tissue engineering
AU - Pang, Qiming
AU - Zu, Jean W.
AU - Siu, Geoffrey M.
AU - Li, Ren Ke
PY - 2010/1
Y1 - 2010/1
N2 - A uniaxial cyclic stretch apparatus is designed and developed for tissue engineering research. The biostretch apparatus employs noncontact electromagnetic force to uniaxially stretch a rectangular Gelfoam® or RTV silicon scaffold. A reliable controller is implemented to control four stretch parameters independently: extent, frequency, pattern, and duration of the stretch. The noncontact driving force together with the specially designed mount allow researchers to use standard Petri dishes and commercially available CO2 incubators to culture an engineered tissue patch under well-defined mechanical conditions. The culture process is greatly simplified over existing processes. Further, beyond traditional uniaxial stretch apparatuses, which provide stretch by fixing one side of the scaffolds and stretching the other side, the new apparatus can also apply uniaxial stretch from both ends simultaneously. Using the biostretch apparatus, the distributions of the strain on the Gelfoam® and GE RTV 6166 silicon scaffolds are quantitatively analyzed.
AB - A uniaxial cyclic stretch apparatus is designed and developed for tissue engineering research. The biostretch apparatus employs noncontact electromagnetic force to uniaxially stretch a rectangular Gelfoam® or RTV silicon scaffold. A reliable controller is implemented to control four stretch parameters independently: extent, frequency, pattern, and duration of the stretch. The noncontact driving force together with the specially designed mount allow researchers to use standard Petri dishes and commercially available CO2 incubators to culture an engineered tissue patch under well-defined mechanical conditions. The culture process is greatly simplified over existing processes. Further, beyond traditional uniaxial stretch apparatuses, which provide stretch by fixing one side of the scaffolds and stretching the other side, the new apparatus can also apply uniaxial stretch from both ends simultaneously. Using the biostretch apparatus, the distributions of the strain on the Gelfoam® and GE RTV 6166 silicon scaffolds are quantitatively analyzed.
KW - Bioreactor
KW - Scaffold
KW - Strain
KW - Uniaxial stretch
UR - http://www.scopus.com/inward/record.url?scp=77955122281&partnerID=8YFLogxK
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U2 - 10.1115/1.3005154
DO - 10.1115/1.3005154
M3 - Article
C2 - 20524751
AN - SCOPUS:77955122281
SN - 0148-0731
VL - 132
JO - Journal of Biomechanical Engineering
JF - Journal of Biomechanical Engineering
IS - 1
ER -