TY - JOUR
T1 - Detection and monitoring of microparticles under skin by optical coherence tomography as an approach to continuous glucose sensing Using Implanted Retroreflectors
AU - Wang, Shang
AU - Sherlock, Tim
AU - Salazar, Betsy
AU - Sudheendran, Narendran
AU - Manapuram, Ravi Kiran
AU - Kourentzi, Katerina
AU - Ruchhoeft, Paul
AU - Willson, Richard C.
AU - Larin, Kirill V.
PY - 2013
Y1 - 2013
N2 - We demonstrate the feasibility of using optical coherence tomography (OCT) to image and detect 2.8 \mu{\rm m} diameter microparticles (stationary and moving) on a highly-reflective gold surface both in clear media and under skin in vitro. The OCT intensity signal can clearly report the microparticle count, and the OCT response to the number of microparticles shows a good linearity. The detect ability of the intensity change (2.9\%\pm 0.5\%) caused by an individual microparticle shows the high sensitivity of monitoring multiple particles using OCT. An optical sensing method based on this feasibility study is described for continuously measuring blood sugar levels in the subcutaneous tissue, and a molecular recognition unit is designed using competitive binding to modulate the number of bound microparticles as a function of glucose concentration. With further development, an ultra-small, implantable sensor might provide high specificity and sensitivity for long-term continuous monitoring of blood glucose concentration.
AB - We demonstrate the feasibility of using optical coherence tomography (OCT) to image and detect 2.8 \mu{\rm m} diameter microparticles (stationary and moving) on a highly-reflective gold surface both in clear media and under skin in vitro. The OCT intensity signal can clearly report the microparticle count, and the OCT response to the number of microparticles shows a good linearity. The detect ability of the intensity change (2.9\%\pm 0.5\%) caused by an individual microparticle shows the high sensitivity of monitoring multiple particles using OCT. An optical sensing method based on this feasibility study is described for continuously measuring blood sugar levels in the subcutaneous tissue, and a molecular recognition unit is designed using competitive binding to modulate the number of bound microparticles as a function of glucose concentration. With further development, an ultra-small, implantable sensor might provide high specificity and sensitivity for long-term continuous monitoring of blood glucose concentration.
KW - Biomedical monitoring
KW - magnetic microparticles
KW - optical coherence tomography
KW - retroreflection
KW - skin
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UR - http://www.scopus.com/inward/citedby.url?scp=84885678747&partnerID=8YFLogxK
U2 - 10.1109/JSEN.2013.2270008
DO - 10.1109/JSEN.2013.2270008
M3 - Article
AN - SCOPUS:84885678747
SN - 1530-437X
VL - 13
SP - 4534
EP - 4541
JO - IEEE Sensors Journal
JF - IEEE Sensors Journal
IS - 11
M1 - 6544228
ER -