Development of an in vitro micro-organ model for pharmacokinetic microanalysis

Robert C. Chang; Binil Starly; Christopher Culbertson; Heidi Holtorf; Steven Gonda; Wei Sun

Development of an in vitro micro-organ model for pharmacokinetic microanalysis

Robert C. Chang
, Binil Starly
, Christopher Culbertson
, Heidi Holtorf
, Steven Gonda
, Wei Sun

Department of Mechanical Engineering

Drexel University
Kansas State University
NASA Johnson Space Center

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

An in vitro model that can realistically and inexpensively predict human response to various drug administration and toxic chemical exposure is needed. By fabricating a microscale 3D tissue analog consisting of an array of channels and tissue-embedded chambers, we can selectively biomimic different mammalian tissues for a multitude of applications, foremost among them experimental pharmaceutical screening for efficacy and toxicity. Our model may be envisioned as an important adjunct for assessing the beneficial and detrimental effects of novel drugs upon navigating a given metabolic pathway. Most exemplary, assessing the therapeutic or toxic effects of a drug on any cell type in vitro may be investigated in the presence of microencapsulated liver cells to take into account the liver-dependent metabolic modification of the candidate drug. Future functional studies will also be conducted for drug therapeutic benefit or toxicity evaluation at a downstream tissue chamber housing a target soft parenchymal tissue to form a multi-compartment tissue chamber.

Original language	English
Title of host publication	Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference, 2006
Pages	183-184
Number of pages	2
State	Published - 2006
Event	IEEE 32nd Annual Northeast Bioengineering Conference, 2006 - Easton, PA, United States Duration: 1 Apr 2006 → 2 Apr 2006

Publication series

Name	Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
Volume	2006
ISSN (Print)	1071-121X

Conference

Conference	IEEE 32nd Annual Northeast Bioengineering Conference, 2006
Country/Territory	United States
City	Easton, PA
Period	1/04/06 → 2/04/06

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 12 Responsible Consumption and Production

Cite this

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title = "Development of an in vitro micro-organ model for pharmacokinetic microanalysis",

abstract = "An in vitro model that can realistically and inexpensively predict human response to various drug administration and toxic chemical exposure is needed. By fabricating a microscale 3D tissue analog consisting of an array of channels and tissue-embedded chambers, we can selectively biomimic different mammalian tissues for a multitude of applications, foremost among them experimental pharmaceutical screening for efficacy and toxicity. Our model may be envisioned as an important adjunct for assessing the beneficial and detrimental effects of novel drugs upon navigating a given metabolic pathway. Most exemplary, assessing the therapeutic or toxic effects of a drug on any cell type in vitro may be investigated in the presence of microencapsulated liver cells to take into account the liver-dependent metabolic modification of the candidate drug. Future functional studies will also be conducted for drug therapeutic benefit or toxicity evaluation at a downstream tissue chamber housing a target soft parenchymal tissue to form a multi-compartment tissue chamber.",

author = "Chang, \{Robert C.\} and Binil Starly and Christopher Culbertson and Heidi Holtorf and Steven Gonda and Wei Sun",

year = "2006",

language = "English",

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series = "Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC",

pages = "183--184",

booktitle = "Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference, 2006",

note = "IEEE 32nd Annual Northeast Bioengineering Conference, 2006 ; Conference date: 01-04-2006 Through 02-04-2006",

}

Chang, RC, Starly, B, Culbertson, C, Holtorf, H, Gonda, S & Sun, W 2006, Development of an in vitro micro-organ model for pharmacokinetic microanalysis. in Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference, 2006., 1629813, Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, vol. 2006, pp. 183-184, IEEE 32nd Annual Northeast Bioengineering Conference, 2006, Easton, PA, United States, 1/04/06.

Development of an in vitro micro-organ model for pharmacokinetic microanalysis. / Chang, Robert C.; Starly, Binil; Culbertson, Christopher et al.
Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference, 2006. 2006. p. 183-184 1629813 (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC; Vol. 2006).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Development of an in vitro micro-organ model for pharmacokinetic microanalysis

AU - Chang, Robert C.

AU - Starly, Binil

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AU - Gonda, Steven

AU - Sun, Wei

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AB - An in vitro model that can realistically and inexpensively predict human response to various drug administration and toxic chemical exposure is needed. By fabricating a microscale 3D tissue analog consisting of an array of channels and tissue-embedded chambers, we can selectively biomimic different mammalian tissues for a multitude of applications, foremost among them experimental pharmaceutical screening for efficacy and toxicity. Our model may be envisioned as an important adjunct for assessing the beneficial and detrimental effects of novel drugs upon navigating a given metabolic pathway. Most exemplary, assessing the therapeutic or toxic effects of a drug on any cell type in vitro may be investigated in the presence of microencapsulated liver cells to take into account the liver-dependent metabolic modification of the candidate drug. Future functional studies will also be conducted for drug therapeutic benefit or toxicity evaluation at a downstream tissue chamber housing a target soft parenchymal tissue to form a multi-compartment tissue chamber.

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M3 - Conference contribution

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SN - 0780395638

SN - 9780780395633

T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC

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BT - Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference, 2006

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ER -

Development of an in vitro micro-organ model for pharmacokinetic microanalysis

Abstract

Publication series

Conference

UN SDGs

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