TY - GEN
T1 - Development of spiral scaffolds with 3D printing-based combinatorial technologies for bone tissue engineering
AU - Kumar, Alok
AU - Yu, Xiaojun
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: The function of bone gets impaired due to the created defects because of injury, trauma and surgical intervention. Currently, repair of bone defects posing a huge economic burden on the health care system with a cost of ~ $2.5 billion [1]. The bone defects remained a challenge, and advanced tissue engineering approach with better strategy is required to regenerate the damaged area [1, 2]. However, most of the tissue engineering scaffolds are unsuccessful in promoting the cell migration inside the pores and therefore, failed to induce the bone ingrowth due to limited nutrient supply related to the geometrical and structural constraints [3]. This leads to the migration of cells seeded inside the pores toward the surface where the nutrient concentration is higher [4]. Therefore, to address this issue, spiral scaffolds had been developed in past using solvent casting method [5]. These spiral structures were found very useful due to open structure, which allows easy cell migration as well as nutrient supply and metabolic waste removal. However, these spiral structures suffer from poor mechanical properties as well as less control on layer thickness and pore architecture within the layer. In this context, three-dimensional (3D) printed porous scaffolds found very promising due to easy to create geometry with interconnected pores. Therefore, in the present work, a spiral-shaped hybrid structure of PLA/PLGA5050-βTCP was designed and prepared. The designed hybrid structure is characterized by a 3D printed PCL scaffold with predefined pores (square-shaped) and these pores were filled with PLGA5050-βTCP (1:1 ratio). The initial construct with no open pores will provide the strength. Importantly, the strength of the construct can be further tailored by the pore geometry. The dissolution of the fast degrading polymer PLGA5050 will help in the pore creation for further enhancing the tissue ingrowth and vascularization at a later stage. Moreover, βTCP will help in the mineralization by supplying the Ca2+ and PO4 3-.
AB - Statement of Purpose: The function of bone gets impaired due to the created defects because of injury, trauma and surgical intervention. Currently, repair of bone defects posing a huge economic burden on the health care system with a cost of ~ $2.5 billion [1]. The bone defects remained a challenge, and advanced tissue engineering approach with better strategy is required to regenerate the damaged area [1, 2]. However, most of the tissue engineering scaffolds are unsuccessful in promoting the cell migration inside the pores and therefore, failed to induce the bone ingrowth due to limited nutrient supply related to the geometrical and structural constraints [3]. This leads to the migration of cells seeded inside the pores toward the surface where the nutrient concentration is higher [4]. Therefore, to address this issue, spiral scaffolds had been developed in past using solvent casting method [5]. These spiral structures were found very useful due to open structure, which allows easy cell migration as well as nutrient supply and metabolic waste removal. However, these spiral structures suffer from poor mechanical properties as well as less control on layer thickness and pore architecture within the layer. In this context, three-dimensional (3D) printed porous scaffolds found very promising due to easy to create geometry with interconnected pores. Therefore, in the present work, a spiral-shaped hybrid structure of PLA/PLGA5050-βTCP was designed and prepared. The designed hybrid structure is characterized by a 3D printed PCL scaffold with predefined pores (square-shaped) and these pores were filled with PLGA5050-βTCP (1:1 ratio). The initial construct with no open pores will provide the strength. Importantly, the strength of the construct can be further tailored by the pore geometry. The dissolution of the fast degrading polymer PLGA5050 will help in the pore creation for further enhancing the tissue ingrowth and vascularization at a later stage. Moreover, βTCP will help in the mineralization by supplying the Ca2+ and PO4 3-.
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M3 - Conference contribution
AN - SCOPUS:85065431390
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 970
BT - Society for Biomaterials Annual Meeting and Exposition 2019
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -