TY - JOUR
T1 - Dimensional, Geometrical, and Physical Constraints in Skull Growth
AU - Weickenmeier, Johannes
AU - Fischer, Cedric
AU - Carter, Dennis
AU - Kuhl, Ellen
AU - Goriely, Alain
N1 - Publisher Copyright:
© 2017 American Physical Society.
PY - 2017/6/16
Y1 - 2017/6/16
N2 - After birth, the skull grows and remodels in close synchrony with the brain to allow for an increase in intracranial volume. Increase in skull area is provided primarily by bone accretion at the sutures. Additional remodeling, to allow for a change in curvatures, occurs by resorption on the inner surface of the bone plates and accretion on their outer surfaces. When a suture fuses too early, normal skull growth is disrupted, leading to a deformed final skull shape. The leading theory assumes that the main stimulus for skull growth is provided by mechanical stresses. Based on these ideas, we first discuss the dimensional, geometrical, and kinematic synchrony between brain, skull, and suture growth. Second, we present two mechanical models for skull growth that account for growth at the sutures and explain the various observed dysmorphologies. These models demonstrate the particular role of physical and geometrical constraints taking place in skull growth.
AB - After birth, the skull grows and remodels in close synchrony with the brain to allow for an increase in intracranial volume. Increase in skull area is provided primarily by bone accretion at the sutures. Additional remodeling, to allow for a change in curvatures, occurs by resorption on the inner surface of the bone plates and accretion on their outer surfaces. When a suture fuses too early, normal skull growth is disrupted, leading to a deformed final skull shape. The leading theory assumes that the main stimulus for skull growth is provided by mechanical stresses. Based on these ideas, we first discuss the dimensional, geometrical, and kinematic synchrony between brain, skull, and suture growth. Second, we present two mechanical models for skull growth that account for growth at the sutures and explain the various observed dysmorphologies. These models demonstrate the particular role of physical and geometrical constraints taking place in skull growth.
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U2 - 10.1103/PhysRevLett.118.248101
DO - 10.1103/PhysRevLett.118.248101
M3 - Article
C2 - 28665667
AN - SCOPUS:85020542320
SN - 0031-9007
VL - 118
JO - Physical Review Letters
JF - Physical Review Letters
IS - 24
M1 - 248101
ER -