TY - GEN
T1 - Direct cell writing of cell encapsulated 3D liver tissue constructs patterned with endothelial cells for pharmacokinetic study
AU - Chang, R.
AU - Nam, J.
AU - Morss, A.
AU - Sun, W.
PY - 2008
Y1 - 2008
N2 - Herein we formulate a methodology to rationally design, model, fabricate, and characterize a 3D bioprinted liver tissue construct on a microfluidic device to serve as an in vitro physiological liver model. By fabricating a 3D in vitro tissue analog consisting of an array of channels with tissue-embedded chambers, one can selectively mimic different mammalian tissues for a multitude of applications for clinical pharmaceutical screening of drug efficacy and toxicity. These constructs are limited in size by diffusion limitations, since adequate nutrients and oxygen must be available to support the high cell density required for recapitulating liver functions. We are therefore developing a novel experimental model in which additional endothelial cells will be patterned within the liver tissue for directed vascularization.
AB - Herein we formulate a methodology to rationally design, model, fabricate, and characterize a 3D bioprinted liver tissue construct on a microfluidic device to serve as an in vitro physiological liver model. By fabricating a 3D in vitro tissue analog consisting of an array of channels with tissue-embedded chambers, one can selectively mimic different mammalian tissues for a multitude of applications for clinical pharmaceutical screening of drug efficacy and toxicity. These constructs are limited in size by diffusion limitations, since adequate nutrients and oxygen must be available to support the high cell density required for recapitulating liver functions. We are therefore developing a novel experimental model in which additional endothelial cells will be patterned within the liver tissue for directed vascularization.
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M3 - Conference contribution
AN - SCOPUS:84869063750
SN - 9781615670802
T3 - 8th World Biomaterials Congress 2008
SP - 1393
BT - 8th World Biomaterials Congress 2008
T2 - 8th World Biomaterials Congress 2008, WBC 2008
Y2 - 28 May 2008 through 1 June 2008
ER -