Direct cell writing of cell encapsulated 3D liver tissue constructs patterned with endothelial cells for pharmacokinetic study

R. Chang, J. Nam, A. Morss, W. Sun

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Herein we formulate a methodology to rationally design, model, fabricate, and characterize a 3D bioprinted liver tissue construct on a microfluidic device to serve as an in vitro physiological liver model. By fabricating a 3D in vitro tissue analog consisting of an array of channels with tissue-embedded chambers, one can selectively mimic different mammalian tissues for a multitude of applications for clinical pharmaceutical screening of drug efficacy and toxicity. These constructs are limited in size by diffusion limitations, since adequate nutrients and oxygen must be available to support the high cell density required for recapitulating liver functions. We are therefore developing a novel experimental model in which additional endothelial cells will be patterned within the liver tissue for directed vascularization.

Original languageEnglish
Title of host publication8th World Biomaterials Congress 2008
Pages1393
Number of pages1
StatePublished - 2008
Event8th World Biomaterials Congress 2008, WBC 2008 - Amsterdam, Netherlands
Duration: 28 May 20081 Jun 2008

Publication series

Name8th World Biomaterials Congress 2008
Volume3

Conference

Conference8th World Biomaterials Congress 2008, WBC 2008
Country/TerritoryNetherlands
CityAmsterdam
Period28/05/081/06/08

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