Abstract
The direct cross-coupling of tautomerizable heterocycles with various unfunctionalized heteroarenes has been achieved through PyBroP-mediated and Pd/Cu-catalyzed sequential C-OH/C-H activation. The methodology allows a facile entry into novel diazine-azole biheterocyclic frameworks. Moreover, an unprecedented Pd-catalyzed phosphonium homocoupling of tautomerizable heterocycles was also developed to afford a direct synthetic route to symmetrical 1,2-, 1,3-, and 1,4-bidiazine units.
Original language | English |
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Pages (from-to) | 1854-1857 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 14 |
Issue number | 7 |
DOIs | |
State | Published - 6 Apr 2012 |