Direct heteroarylation of tautomerizable heterocycles into unsymmetrical and symmetrical biheterocycles via Pd/Cu-catalyzed phosphonium coupling

Abhishek Sharma, Dipak Vachhani, Erik Van Der Eycken

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The direct cross-coupling of tautomerizable heterocycles with various unfunctionalized heteroarenes has been achieved through PyBroP-mediated and Pd/Cu-catalyzed sequential C-OH/C-H activation. The methodology allows a facile entry into novel diazine-azole biheterocyclic frameworks. Moreover, an unprecedented Pd-catalyzed phosphonium homocoupling of tautomerizable heterocycles was also developed to afford a direct synthetic route to symmetrical 1,2-, 1,3-, and 1,4-bidiazine units.

Original languageEnglish
Pages (from-to)1854-1857
Number of pages4
JournalOrganic Letters
Volume14
Issue number7
DOIs
StatePublished - 6 Apr 2012

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