TY - JOUR
T1 - Drastic sensing enhancement using acoustic bubbles for surface-based microfluidic sensors
AU - De Vellis, Andrea
AU - Gritsenko, Dmitry
AU - Lin, Yang
AU - Wu, Zhenping
AU - Zhang, Xian
AU - Pan, Yayue
AU - Xue, Wei
AU - Xu, Jie
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - There is a high demand for ultrafast biosensors for industrial and public health applications. However, the performance of existing sensors is often limited by the slow mass transport process in traditional pressure-driven microfluidic devices. In this paper, we show for the first time that acoustic microbubbles trapped in prefabricated cavities in a micro-chamber are capable of enhancing fluid sample mixing that results in faster delivery of target species to the sensor surface. We demonstrate a drastic reduction of sensor response time (up to 21.3-fold) for surface-based nanosensors in presence of resonantly actuated microbubbles. The obtained results are valid in a wide pH (4–10) range and agree well with previous studies.
AB - There is a high demand for ultrafast biosensors for industrial and public health applications. However, the performance of existing sensors is often limited by the slow mass transport process in traditional pressure-driven microfluidic devices. In this paper, we show for the first time that acoustic microbubbles trapped in prefabricated cavities in a micro-chamber are capable of enhancing fluid sample mixing that results in faster delivery of target species to the sensor surface. We demonstrate a drastic reduction of sensor response time (up to 21.3-fold) for surface-based nanosensors in presence of resonantly actuated microbubbles. The obtained results are valid in a wide pH (4–10) range and agree well with previous studies.
KW - Microfluidics
KW - Microstreaming
KW - Resonant frequency
KW - Sensing enhancement
UR - http://www.scopus.com/inward/record.url?scp=85000774288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85000774288&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2016.11.098
DO - 10.1016/j.snb.2016.11.098
M3 - Article
AN - SCOPUS:85000774288
SN - 0925-4005
VL - 243
SP - 298
EP - 302
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
ER -