TY - JOUR
T1 - Dynamic agent of an injectable and self-healing drug-loaded hydrogel for embolization therapy
AU - Zhou, Xiaqing
AU - Li, Yongsan
AU - Chen, Shuang
AU - Fu, Ya nan
AU - Wang, Shihui
AU - Li, Guofeng
AU - Tao, Lei
AU - Wei, Yen
AU - Wang, Xing
AU - Liang, Jun F.
N1 - Publisher Copyright:
© 2018
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Embolic agents are crucial for trans-catheter arterial embolization (TAE) in the treatment of various unresectable malignant tumors. Although solid particles, liquid oils, and some polymeric hydrogels have proved their capacities for embolic therapies, the low efficiency, time sensitivity, and cytotoxicity are still considered as challenges. In this study, we developed a three-component dynamic self-healing hydrogel to overcome these limitations. With the help of the Schiff-base bonding, both glycol-chitosan and carbazochrome, containing amine groups, react with dibenzaldehyde-terminated poly(ethylene-glycol) (DF-PEG), forming the dynamic self-healing hydrogels under a mild condition within 200 s. 1 H NMR and rheology test were used to characterize the Schiff-base formation and mechanical strength. Controlled-release of carbazochrome from different gelator concentrations of DF-PEG was also studied. Furthermore, in vivo evaluation of the embolization on rats showed the superior embolic effects of the injectable and self-healing hydrogel. Therefore, this new dynamic agent demonstrated the potential for application as a simple, inexpensive, and tunable embolic agent for cancer treatment and drug delivery system.
AB - Embolic agents are crucial for trans-catheter arterial embolization (TAE) in the treatment of various unresectable malignant tumors. Although solid particles, liquid oils, and some polymeric hydrogels have proved their capacities for embolic therapies, the low efficiency, time sensitivity, and cytotoxicity are still considered as challenges. In this study, we developed a three-component dynamic self-healing hydrogel to overcome these limitations. With the help of the Schiff-base bonding, both glycol-chitosan and carbazochrome, containing amine groups, react with dibenzaldehyde-terminated poly(ethylene-glycol) (DF-PEG), forming the dynamic self-healing hydrogels under a mild condition within 200 s. 1 H NMR and rheology test were used to characterize the Schiff-base formation and mechanical strength. Controlled-release of carbazochrome from different gelator concentrations of DF-PEG was also studied. Furthermore, in vivo evaluation of the embolization on rats showed the superior embolic effects of the injectable and self-healing hydrogel. Therefore, this new dynamic agent demonstrated the potential for application as a simple, inexpensive, and tunable embolic agent for cancer treatment and drug delivery system.
KW - Carbazochrome
KW - Embolic agent
KW - Schiff-base bonding
KW - Self-Healing hydrogel
KW - TAE
UR - http://www.scopus.com/inward/record.url?scp=85053198081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053198081&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2018.09.016
DO - 10.1016/j.colsurfb.2018.09.016
M3 - Article
C2 - 30219579
AN - SCOPUS:85053198081
SN - 0927-7765
VL - 172
SP - 601
EP - 607
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -