@inproceedings{fccd83c8992545ce9beb3a67d510b14a,
title = "Dynamic OCE measurement of the biomechanical properties of gelatin phantom and mouse cornea in vivo",
abstract = "Here we demonstrate our use of phase stabilized swept-source optical coherence elastography (PhS-SSOCE) to assess elastic wave propagation in gelatin phantoms. From these measurements, Young's moduli of the samples were determined. Low-amplitude (<10μm) mechanical waves were introduced using a focused air pulse on gelatin of different concentrations. Elastic wave amplitude and velocity were measured at multiple points on the phantom surface using a phase-resolved method. The results demonstrate that this method is capable of resolving very small changes in wave amplitude (∼ 10 nm) as well as differences in wave velocity due to material stiffness. We further demonstrate use of this method for measurements with a contact lens, a silicone eye model and with the eye of an 18-month-old mouse in vivo. This non-destructive, non-invasive measurement system produces minimal tissue excitation and has high measurement sensitivity. These traits make this make this method useful for in vivo study of the biomechanical properties of ocular and other tissues.",
keywords = "Biomechanics, OCE, OCT, air pulse pulse, elastography, in vivo, noninvasive",
author = "Jiasong Li and Shang Wang and Manapuram, {Ravi Kiran} and Menodiado, {Floredes M.} and Manmohan Singh and Salavat Aglyamov and Stanislav Emelianov and Michael Twa and Larin, {Kirill V.}",
year = "2013",
doi = "10.1117/12.2007033",
language = "English",
isbn = "9780819493408",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII",
note = "Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII ; Conference date: 04-02-2013 Through 06-02-2013",
}