Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo

Jiasong Li, Shang Wang, Ravi Kiran Manapuram, Manmohan Singh, Floredes M. Menodiado, Salavat Aglyamov, Stanislav Emelianov, Michael D. Twa, Kirill V. Larin

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Abstract

We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in vivo. The results show that the wave velocity can be quantified from the analysis of wave propagation, thereby enabling the estimation of the sample elasticity using the model of surface wave propagation for the tissue-mimicking phantoms. This noninvasive, noncontact measurement technique involves low-force methods of tissue excitation that can be potentially used to assess the biomechanical properties of ocular and other delicate tissues in vivo.

Original languageEnglish
Article number121503
JournalJournal of Biomedical Optics
Volume18
Issue number12
DOIs
StatePublished - 2013

Keywords

  • Optical coherence tomography
  • Young's modulus
  • air puff
  • mouse cornea
  • noninvasive detection
  • surface elastic wave

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