TY - JOUR
T1 - Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo
AU - Li, Jiasong
AU - Wang, Shang
AU - Manapuram, Ravi Kiran
AU - Singh, Manmohan
AU - Menodiado, Floredes M.
AU - Aglyamov, Salavat
AU - Emelianov, Stanislav
AU - Twa, Michael D.
AU - Larin, Kirill V.
PY - 2013
Y1 - 2013
N2 - We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in vivo. The results show that the wave velocity can be quantified from the analysis of wave propagation, thereby enabling the estimation of the sample elasticity using the model of surface wave propagation for the tissue-mimicking phantoms. This noninvasive, noncontact measurement technique involves low-force methods of tissue excitation that can be potentially used to assess the biomechanical properties of ocular and other delicate tissues in vivo.
AB - We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in vivo. The results show that the wave velocity can be quantified from the analysis of wave propagation, thereby enabling the estimation of the sample elasticity using the model of surface wave propagation for the tissue-mimicking phantoms. This noninvasive, noncontact measurement technique involves low-force methods of tissue excitation that can be potentially used to assess the biomechanical properties of ocular and other delicate tissues in vivo.
KW - Optical coherence tomography
KW - Young's modulus
KW - air puff
KW - mouse cornea
KW - noninvasive detection
KW - surface elastic wave
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U2 - 10.1117/1.JBO.18.12.121503
DO - 10.1117/1.JBO.18.12.121503
M3 - Article
C2 - 24089292
AN - SCOPUS:84887973648
SN - 1083-3668
VL - 18
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 12
M1 - 121503
ER -