TY - CHAP
T1 - Electrospun nanofibers for drug delivery
AU - Stack, Mary
AU - Parikh, Deep
AU - Wang, Haoyu
AU - Wang, Lichen
AU - Xu, Meng
AU - Zou, Jin
AU - Cheng, Jun
AU - Wang, Hongjun
N1 - Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Electrospinning, a high-voltage-driven spinning technique, has the ability to fabricate multiscale fibers from a variety of materials. Its relatively high production rate, low setup cost, and easy operation receive great attention in material sciences and biomedical applications, especially in tissue regeneration and drug delivery. It is predominantly applied to polymeric materials, including synthetic, natural, or blended polymers. The possibility of temporospatially incorporating and releasing various bioactive molecules from electrospun fibers and yielding anisotropic fiber organization enables the recapitulation of the major features of native extracellular matrix and supports the adhesion and growth of various cells. Increasing evidence has proved their utility as biomimetic substrates for regenerating a variety of tissues, such as skin, bone, cardiovascular tissue, cornea, nerve, and many more. In this regard, this chapter first summarizes how various approaches have been taken to incorporate drugs (hydrophobic, hydrophilic, small-molecule, large-molecule, etc.) onto/into electrospun fibers, then discusses the drug release from the functionalized fibrous systems, and, at the end, highlights the utility of such multifunctional fibrous matrices for neural, vascular, cardiac, skin, and bone tissue engineering.
AB - Electrospinning, a high-voltage-driven spinning technique, has the ability to fabricate multiscale fibers from a variety of materials. Its relatively high production rate, low setup cost, and easy operation receive great attention in material sciences and biomedical applications, especially in tissue regeneration and drug delivery. It is predominantly applied to polymeric materials, including synthetic, natural, or blended polymers. The possibility of temporospatially incorporating and releasing various bioactive molecules from electrospun fibers and yielding anisotropic fiber organization enables the recapitulation of the major features of native extracellular matrix and supports the adhesion and growth of various cells. Increasing evidence has proved their utility as biomimetic substrates for regenerating a variety of tissues, such as skin, bone, cardiovascular tissue, cornea, nerve, and many more. In this regard, this chapter first summarizes how various approaches have been taken to incorporate drugs (hydrophobic, hydrophilic, small-molecule, large-molecule, etc.) onto/into electrospun fibers, then discusses the drug release from the functionalized fibrous systems, and, at the end, highlights the utility of such multifunctional fibrous matrices for neural, vascular, cardiac, skin, and bone tissue engineering.
KW - Drug delivery
KW - Electrospinning
KW - Multifunctional fiber
KW - Nanofiber
KW - Nanoparticle
KW - Tissue regeneration
UR - http://www.scopus.com/inward/record.url?scp=85082276655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85082276655&partnerID=8YFLogxK
U2 - 10.1016/B978-0-323-51270-1.00025-X
DO - 10.1016/B978-0-323-51270-1.00025-X
M3 - Chapter
AN - SCOPUS:85082276655
SN - 9780128134412
SP - 735
EP - 764
BT - Electrospinning
ER -