TY - GEN
T1 - Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems
AU - Kayaalp Nalbant, Elif
AU - Liu, Wenqiang
AU - Pehlivan, Hande
AU - Shah, Shailee
AU - Puskar, Anessa
AU - Sampath, Meghna
AU - Mieler, William F.
AU - Kang-Mieler, Jennifer J.
AU - Tichauer, Kenneth M.
N1 - Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2020
Y1 - 2020
N2 - Fluorescein videoangiography is often used to visualize diabetic retinopathy (DR), a degenerative disease characterized by degradation of retinal blood vessels. However, more sensitive and quantitative measures of increased vessel permeability in the asymptomatic phase of DR (non-proliferative DR) could help identify patients who would benefit from therapeutic intervention to avoid vision loss. Here, a modified "adiabatic approximation to the tissue-homogeneity model"was shown in simulations and rat experiments to estimate extraction fraction within a 20%-error for physiological ranges of vascular permeability expected in nonproliferative DR, even in low-dynamic-range (8-bit) fluorescein imaging systems that are standard in many institutes.
AB - Fluorescein videoangiography is often used to visualize diabetic retinopathy (DR), a degenerative disease characterized by degradation of retinal blood vessels. However, more sensitive and quantitative measures of increased vessel permeability in the asymptomatic phase of DR (non-proliferative DR) could help identify patients who would benefit from therapeutic intervention to avoid vision loss. Here, a modified "adiabatic approximation to the tissue-homogeneity model"was shown in simulations and rat experiments to estimate extraction fraction within a 20%-error for physiological ranges of vascular permeability expected in nonproliferative DR, even in low-dynamic-range (8-bit) fluorescein imaging systems that are standard in many institutes.
KW - Fluorescein videoangiography
KW - Low-dynamic range
KW - Mathematical model
KW - Retinopathy
UR - http://www.scopus.com/inward/record.url?scp=85094179582&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094179582&partnerID=8YFLogxK
U2 - 10.1117/12.2546442
DO - 10.1117/12.2546442
M3 - Conference contribution
AN - SCOPUS:85094179582
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Ophthalmic Technologies XXX
A2 - Manns, Fabrice
A2 - Ho, Arthur
A2 - Soderberg, Per G.
T2 - 30th Conference on Ophthalmic Technologies
Y2 - 1 February 2020 through 2 February 2020
ER -