Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems

Elif Kayaalp Nalbant; Wenqiang Liu; Hande Pehlivan; Shailee Shah; Anessa Puskar; Meghna Sampath; William F. Mieler; Jennifer J. Kang-Mieler; Kenneth M. Tichauer

doi:10.1117/12.2546442

Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems

Elif Kayaalp Nalbant, Wenqiang Liu, Hande Pehlivan, Shailee Shah, Anessa Puskar, Meghna Sampath, William F. Mieler, Jennifer J. Kang-Mieler, Kenneth M. Tichauer

Department of Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Fluorescein videoangiography is often used to visualize diabetic retinopathy (DR), a degenerative disease characterized by degradation of retinal blood vessels. However, more sensitive and quantitative measures of increased vessel permeability in the asymptomatic phase of DR (non-proliferative DR) could help identify patients who would benefit from therapeutic intervention to avoid vision loss. Here, a modified "adiabatic approximation to the tissue-homogeneity model"was shown in simulations and rat experiments to estimate extraction fraction within a 20%-error for physiological ranges of vascular permeability expected in nonproliferative DR, even in low-dynamic-range (8-bit) fluorescein imaging systems that are standard in many institutes.

Original language	English
Title of host publication	Ophthalmic Technologies XXX
Editors	Fabrice Manns, Arthur Ho, Per G. Soderberg
ISBN (Electronic)	9781510631991
DOIs	https://doi.org/10.1117/12.2546442
State	Published - 2020
Event	30th Conference on Ophthalmic Technologies - San Francisco, United States Duration: 1 Feb 2020 → 2 Feb 2020

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11218
ISSN (Print)	1605-7422

Conference

Conference	30th Conference on Ophthalmic Technologies
Country/Territory	United States
City	San Francisco
Period	1/02/20 → 2/02/20

Keywords

Fluorescein videoangiography
Low-dynamic range
Mathematical model
Retinopathy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.2546442

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Kayaalp Nalbant, E., Liu, W., Pehlivan, H., Shah, S., Puskar, A., Sampath, M., Mieler, W. F., Kang-Mieler, J. J., & Tichauer, K. M. (2020). Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems. In F. Manns, A. Ho, & P. G. Soderberg (Eds.), Ophthalmic Technologies XXX Article 1121823 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11218). https://doi.org/10.1117/12.2546442

Kayaalp Nalbant, Elif ; Liu, Wenqiang ; Pehlivan, Hande et al. / Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems. Ophthalmic Technologies XXX. editor / Fabrice Manns ; Arthur Ho ; Per G. Soderberg. 2020. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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abstract = "Fluorescein videoangiography is often used to visualize diabetic retinopathy (DR), a degenerative disease characterized by degradation of retinal blood vessels. However, more sensitive and quantitative measures of increased vessel permeability in the asymptomatic phase of DR (non-proliferative DR) could help identify patients who would benefit from therapeutic intervention to avoid vision loss. Here, a modified {"}adiabatic approximation to the tissue-homogeneity model{"}was shown in simulations and rat experiments to estimate extraction fraction within a 20\%-error for physiological ranges of vascular permeability expected in nonproliferative DR, even in low-dynamic-range (8-bit) fluorescein imaging systems that are standard in many institutes.",

keywords = "Fluorescein videoangiography, Low-dynamic range, Mathematical model, Retinopathy",

author = "\{Kayaalp Nalbant\}, Elif and Wenqiang Liu and Hande Pehlivan and Shailee Shah and Anessa Puskar and Meghna Sampath and Mieler, \{William F.\} and Kang-Mieler, \{Jennifer J.\} and Tichauer, \{Kenneth M.\}",

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year = "2020",

doi = "10.1117/12.2546442",

language = "English",

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Kayaalp Nalbant, E, Liu, W, Pehlivan, H, Shah, S, Puskar, A, Sampath, M, Mieler, WF, Kang-Mieler, JJ & Tichauer, KM 2020, Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems. in F Manns, A Ho & PG Soderberg (eds), Ophthalmic Technologies XXX., 1121823, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11218, 30th Conference on Ophthalmic Technologies, San Francisco, United States, 1/02/20. https://doi.org/10.1117/12.2546442

Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems. / Kayaalp Nalbant, Elif; Liu, Wenqiang; Pehlivan, Hande et al.
Ophthalmic Technologies XXX. ed. / Fabrice Manns; Arthur Ho; Per G. Soderberg. 2020. 1121823 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11218).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Kayaalp Nalbant, Elif

AU - Liu, Wenqiang

AU - Pehlivan, Hande

AU - Shah, Shailee

AU - Puskar, Anessa

AU - Sampath, Meghna

AU - Mieler, William F.

AU - Kang-Mieler, Jennifer J.

AU - Tichauer, Kenneth M.

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PY - 2020

Y1 - 2020

N2 - Fluorescein videoangiography is often used to visualize diabetic retinopathy (DR), a degenerative disease characterized by degradation of retinal blood vessels. However, more sensitive and quantitative measures of increased vessel permeability in the asymptomatic phase of DR (non-proliferative DR) could help identify patients who would benefit from therapeutic intervention to avoid vision loss. Here, a modified "adiabatic approximation to the tissue-homogeneity model"was shown in simulations and rat experiments to estimate extraction fraction within a 20%-error for physiological ranges of vascular permeability expected in nonproliferative DR, even in low-dynamic-range (8-bit) fluorescein imaging systems that are standard in many institutes.

AB - Fluorescein videoangiography is often used to visualize diabetic retinopathy (DR), a degenerative disease characterized by degradation of retinal blood vessels. However, more sensitive and quantitative measures of increased vessel permeability in the asymptomatic phase of DR (non-proliferative DR) could help identify patients who would benefit from therapeutic intervention to avoid vision loss. Here, a modified "adiabatic approximation to the tissue-homogeneity model"was shown in simulations and rat experiments to estimate extraction fraction within a 20%-error for physiological ranges of vascular permeability expected in nonproliferative DR, even in low-dynamic-range (8-bit) fluorescein imaging systems that are standard in many institutes.

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KW - Mathematical model

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Kayaalp Nalbant E, Liu W, Pehlivan H, Shah S, Puskar A, Sampath M et al. Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems. In Manns F, Ho A, Soderberg PG, editors, Ophthalmic Technologies XXX. 2020. 1121823. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2546442

Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems

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Keywords

UN SDGs

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