@inproceedings{6e65d7bd0081446382524c9b87e8ed9a,
title = "Estimating retinal vascular permeability using the adiabatic approximation to the tissue homogeneity model with fluorescein videoangiography",
abstract = "Clinical symptoms of diabetic retinopathy are not detectable until damage to the retina reaches an irreversible stage, at least by today's treatment standards. As a result, there is a push to develop new, {"}sub-clinical{"} methods of predicting the onset of diabetic retinopathy before the onset of irreversible damage. With diabetic retinopathy being associated with the accumulation of long-term mild damage to the retinal vasculature, retinal blood vessel permeability has been proposed as a key parameter for detecting preclinical stages of retinopathy. In this study, a kinetic modeling approach used to quantify vascular permeability in dynamic contrast-enhanced medical imaging was evaluated in noise simulations and then applied to retinal videoangiography data in a diabetic rat for the first time to determine the potential for this approach to be employed clinically as an early indicator of diabetic retinopathy. Experimental levels of noise were found to introduce errors of less than 15% in estimates of blood flow and extraction fraction (a marker of vascular permeability), and fitting of rat retinal fluorescein angiography data provided stable maps of both parameters.",
keywords = "diabetic retinopathy, fluorescence, kinetic modeling, rat, retinal blood flow, streptozotocin",
author = "Tichauer, {Kenneth M.} and Osswald, {Christian R.} and Emily Dosmar and Guthrie, {Micah J.} and Logan Hones and Lagnojita Sinha and Xiaochun Xu and Mieler, {William F.} and {St. Lawrence}, Keith and Kang-Mieler, {Jennifer J.}",
note = "Publisher Copyright: {\textcopyright} 2015 Copyright SPIE.; Biophotonics South America ; Conference date: 23-05-2015 Through 25-05-2015",
year = "2015",
doi = "10.1117/12.2180643",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
editor = "Katarina Svanberg and Cristina Kurachi and Bagnato, {Vanderlei Salvador} and Tromberg, {Bruce J.}",
booktitle = "Biophotonics South America",
}